Expression of L-type amino acid transporter 1 (LAT1) in neuroendocrine tumors of the lung

被引：64

作者：

Kaira, Kyoichi ^{[1
]}

Oriuchi, Noboru ^{[2
]}

Imai, Hisao ^{[1
]}

Shimizu, Kimihiro ^{[3
]}

Yanagitani, Noriko ^{[1
]}

Sunaga, Noriaki ^{[1
]}

Hisada, Takeshi ^{[1
]}

Kawashima, Osamu ^{[4
]}

Iijima, Hironobu ^{[5
]}

Ishizuka, Tamotsu ^{[1
]}

Kanai, Yoshikatsu ^{[6
]}

Endou, Hitoshi ^{[7
]}

Nakajima, Takashi ^{[8
]}

Mori, Masatomo ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Med, Dept Med & Mol Sci, Gunma 3718511, Japan

[2] Gunma Univ, Grad Sch Med, Dept Diagnost Radiol & Nucl Med, Gunma 3718511, Japan

[3] Gunma Univ, Grad Sch Med, Dept Thorac & Visceral Organ Surg, Gunma 3718511, Japan

[4] Natl Nishi Gunma Hosp, Dept Surg, Gunma, Japan

[5] Natl Nishi Gunma Hosp, Dept Resp Med, Gunma, Japan

[6] Osaka Univ, Grad Sch Med, Div Biosyst Pharmacol, Dept Pharmacol, Suita, Osaka 565, Japan

[7] Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, Tokyo, Japan

[8] Gunma Univ, Grad Sch Med, Dept Tumor Pathol, Gunma 3718511, Japan

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2008年 / 204卷 / 08期

关键词：

lung cancer; neuroendocrine tumor; amino acid transporter 1; large cell neuroendocrine carcinoma; Ki-67;

D O I：

10.1016/j.prp.2008.02.003

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Amino acid transport systems play an important role in cellular proliferation. L-type amino acid transporter 1 (LAT1) has been associated with tumor growth, and is highly expressed in the established tumor cell lines and primary human neoplasms. In this study, we investigated the expression of LAT1 to evaluate the malignant potential and prognostic significance in neuroendocrine (NE) tumors of the lung. Twenty-one surgically resected, large cell neuroendocrine carcinomas (LCNEC), 13 small cell lung cancers (SCLC), five atypical carcinoids (AC), and 10 typical carcinoids (TC) were enrolled in the study. LAT1 expression and Ki-67 labeling index of the NE tumors were analyzed by immunohistochemical staining. LAT1 was overexpressed in 52.4% of the LCNEC, in 46.2% of the SCLC, and in 25% of the AC. LAT1 expression in LCNEC was significantly associated with lymph node metastasis and poor outcome. Moreover, a significant correlation was found between LAT1 expression and Ki-67 in both LCNEC and SCLC. Expression of LAT1 tended to increase from low-grade to high-grade NE tumors. The present results suggest that LAT1 may play a significant role in cellular proliferation, lymph node metastasis, and poor outcome in patients with NE tumors of the lung. (c) 2008 Elsevier GmbH. All rights reserved.

引用

页码：553 / 561

页数：9

共 29 条

[11] Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98) [J].

Kanai, Y ;

Segawa, H ;

Miyamoto, K ;

Uchino, H ;

Takeda, E ;

Endou, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (37) :23629-23632

[12] Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells [J].

Kim, D ;

Kanai, Y ;

Choi, HW ;

Tangtrongsup, S ;

Chairoungdua, A ;

Babu, E ;

Tachampa, K ;

Anzai, N ;

Iribe, Y ;

Endou, H .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2002, 1565 (01) :112-122

[13] Expression of L-type amino acid transporter 1 (LAT1) in esophageal carcinoma [J].

Kobayashi, H ;

Ishii, Y ;

Takayama, T .

JOURNAL OF SURGICAL ONCOLOGY, 2005, 90 (04) :233-238

[14] Expression of a system L neutral amino acid transporter at the blood-brain barrier [J].

Matsuo, H ;

Tsukada, S ;

Nakata, T ;

Chairoungdua, A ;

Kim, DK ;

Cha, SH ;

Inatomi, J ;

Yorifuji, H ;

Fukuda, J ;

Endou, H ;

Kanai, Y .

NEUROREPORT, 2000, 11 (16) :3507-3511

[15] REGULATORY AND MOLECULAR ASPECTS OF MAMMALIAN AMINO-ACID-TRANSPORT [J].

MCGIVAN, JD ;

PASTORANGLADA, M .

BIOCHEMICAL JOURNAL, 1994, 299 :321-334

[16] LAT1 expression in normal lung and in atypical adenomatous hyperplasia and adenocarcinoma of the lung [J].

Nakanishi, K ;

Matsuo, H ;

Kanai, Y ;

Endou, H ;

Hiroi, S ;

Tominaga, S ;

Mukai, M ;

Ikeda, E ;

Ozeki, Y ;

Aida, S ;

Kawai, T .

VIRCHOWS ARCHIV, 2006, 448 (02) :142-150

[17] L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors [J].

Nawashiro, Hiroshi ;

Otani, Naoki ;

Shinomiya, Nariyoshi ;

Fukui, Shinji ;

Ooigawa, Hidetoshi ;

Shima, Katsuji ;

Matsuo, Hirotaka ;

Kanai, Yoshikatsu ;

Endou, Hitoshi .

INTERNATIONAL JOURNAL OF CANCER, 2006, 119 (03) :484-492

[18] Expression of l-type amino acid transporter 1 (LAT1) and 4F2 heavy chain (4F2hc) in liver tumor lesions of rat models [J].

Ohkame, H ;

Masuda, H ;

Ishii, Y ;

Kanai, Y .

JOURNAL OF SURGICAL ONCOLOGY, 2001, 78 (04) :265-271

[19] Present role and future prospects of positron emission tomography in clinical oncology [J].

Oriuchi, Noboru ;

Higuchi, Tetsuya ;

Ishikita, Tomohiro ;

Miyakubo, Mitsuyuki ;

Hanaoka, Hirofumi ;

Iida, Yasuhiko ;

Endo, Keigo .

CANCER SCIENCE, 2006, 97 (12) :1291-1297

[20] EVIDENCE FOR 2 TYPES OF MEDIATION OF NEUTRAL AMINO-ACID TRANSPORT IN EHRILICH CELLS [J].

OXENDER, DL ;

CHRISTENSEN, HN .

NATURE, 1963, 197 (486) :765-&

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