Identification of high risk breast-cancer patients by gene expression profiling

被引：129

作者：

Ahr, A ^{[1
]}

Karn, T ^{[1
]}

Solbach, C ^{[1
]}

Seiter, T ^{[1
]}

Strebhardt, K ^{[1
]}

Holtrich, U ^{[1
]}

Kaufmann, M ^{[1
]}

机构：

[1] Univ Frankfurt, Dept Obstet & Gynecol, D-60590 Frankfurt, Germany

来源：

LANCET | 2002年 / 359卷 / 9301期

关键词：

D O I：

10.1016/S0140-6736(02)07337-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We previously used DNA array analyses in the molecular profiling of breast cancers. By cluster analysis of 55 patients, we Identified a subpopulation of breast cancers-designated class A-that contained a high number of nodal-positive tumours and that had frequently developed distant metastases at the time of diagnosis. We have now analysed follow-up data from these patients. We found that, despite a median of only 23.5 months of follow-up, 11 of 22 patients In class A progressed to metastatic disease, and three of five patients classified as having a nodal status of NO In this subpopulation developed distant metastases. Our analysis Identifies breast-cancer patients with a high risk of disease recurrence, and could act as a first step towards Improved patient-adapted therapy.

引用

页码：131 / 132

页数：2

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