The molecular biology of the SIR proteins

被引：223

作者：

Gasser, SM

Cockell, MM

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva, Switzerland

[2] Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland

来源：

GENE | 2001年 / 279卷 / 01期

关键词：

chromatin; transcriptional repression; telomeric position effect; HM loci; silent information regulator; histone deacetylase;

D O I：

10.1016/S0378-1119(01)00741-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Silent or heritably repressed genes constitute the major fraction of genetic information in higher eukaryotic cells. Budding yeast has very little consecutively repressed DNA, but what exists has served as a paradigm for the molecular analysis of heterochromatin. The major structural constituents of repressed chromatin in yeast are the four core histones and three large chromatin factors called Silent information regulators 2, 3 and 4. How these components assemble DNA into a state that is refractory to transcription remains a mystery. Nonetheless, there have been many recent insights into their molecular structures. This review examines the impact of these results on our understanding of silencing function in budding yeast. (C) 2001 Published by Elsevier Science B.V.

引用

页码：1 / 16

页数：16

共 161 条

[1] Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2 [J].