Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis

被引:313
作者
Amiet, Claire [1 ,8 ]
Gourfinkel-An, Isabelle [2 ,3 ]
Bouzamondo, Anissa [4 ]
Tordjman, Sylvie [7 ]
Baulac, Michel [2 ,3 ]
Lechat, Philippe [4 ]
Mottron, Laurent [5 ,6 ]
Cohen, David [1 ,8 ]
机构
[1] Univ Paris 06, Grp Hosp Pitie Salpetriere, APHP, Dept Child & Adolescent Psychiat, F-75013 Paris, France
[2] Univ Paris 06, Grp Hosp Pitie Salpetriere, APHP, Ctr Epileptol, F-75013 Paris, France
[3] Univ Paris 06, Grp Hosp Pitie Salpetriere, APHP, Reference Ctr Rare Epilepsies, F-75013 Paris, France
[4] Univ Paris 06, Grp Hosp Pitie Salpetriere, APHP, Dept Pharmacol, F-75013 Paris, France
[5] Univ Montreal, Dept Psychiat, Montreal, PQ H3C 3J7, Canada
[6] Univ Montreal, Hop Riviere Prairies, Montreal, PQ H3C 3J7, Canada
[7] Univ Rennes, CHU Guilaume Regnier, Dept Child & Adolescent Psychiat, Rennes, France
[8] CNRS, Lab Psychol & Neurosci Cognit, UMR 8189, Paris, France
基金
加拿大健康研究院;
关键词
autism; epilepsy; gender; intellectual disability; meta-analysis;
D O I
10.1016/j.biopsych.2008.04.030
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background: The association between epilepsy and autism is consistently reported, with a wide range of prevalence rates. This may be attributed to the heterogeneity of the samples with respect to age, comorbidity, sex, and intellectual disability (ID). We aimed to compare the prevalence of epilepsy 1) among autistic patients with ID versus autistic patients without ID and 2) among male versus female autistic patients. Methods: We reviewed all data available from published reports (1963-2006) on autism and epilepsy and conducted a meta-analysis of 10 and 14 studies, respectively, to assess the relative risk (RR) of epilepsy in autism according to ID and gender. The pooled groups included 2112 (627 with IQ : 70, 1485 with IQ < 70) and 1530 (1191 male, 339 female) patients, respectively. Results: There was a strong discrepancy in relative risk (RR) according to IQ, with more autistic patients with ID having epilepsy (RR = .555; 95% confidence interval [CI]:.42-.73; p<.001). The pooled prevalence of epilepsy was 21.5% in autistic subjects with ID versus 8% in autistic subjects without ID. There was a strong discrepancy in RR according to sex, favoring comorbidity of epilepsy in autistic girls (RR = .549; 95% CI:.45-.66; p<.001). The male:female ratio of autism comorbid with epilepsy was close to 2:1 whereas the male:female ratio of autism without epilepsy was 3.51. Conclusions: The results of this meta-analysis indicate that risk for epilepsy in autism is a function of ID severity and distinguishes autism associated with epilepsy as a subgroup of autism by its male-female ratio.
引用
收藏
页码:577 / 582
页数:6
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