LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor

被引：47

作者：

Gao, Yijun ^{[1
]}

Ge, Gaoxiang ^{[2
]}

Ji, Hongbin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China

来源：

PROTEIN & CELL | 2011年 / 2卷 / 02期

基金：

中国国家自然科学基金;

关键词：

liver kinase B1; lung cancer; tumor suppressor; PEUTZ-JEGHERS-SYNDROME; ACTIVATED PROTEIN-KINASE; HEMATOPOIETIC STEM-CELLS; CANCER PROGRESSION; SOMATIC MUTATIONS; KNOCKOUT MICE; GENE; ADENOCARCINOMAS; LKB1/STK11; PATHWAY;

D O I：

10.1007/s13238-011-1021-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Lung cancer is featured with high mortality, with a 15% five-year survival rate worldwide. Genetic alterations, such as loss of function of tumor suppressor genes, frequently contribute to lung cancer initiation, progression and metastasis. Liver kinase B1 (LKB1), as a serine/threonine kinase and tumor suppressor, is frequently mutated and inactivated in non-small cell lung cancer (NSCLC). Recent studies have provided strong evidences that LKB1 loss promotes lung cancerigenesis process, especially lung cancer progression and metastasis. This review will summarize recent progress on how LKB1 modulates the process of lung cancerigenesis, emphasizing on LKB1 downstream signaling pathways and biological functions. We will further discuss the potential development of prognostic biomarkers or therapeutic targets in lung cancer clinic based on the molecular alteration associated with deregulated LKB1 signaling.

引用

页码：99 / 107

页数：9

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