Hypervalent iodine oxidation of indolic 2-oxazolines

被引：29

作者：

Braun, NA

Bray, JD

Ciufolini, MA

机构：

[1] Univ Lyon 1, F-69622 Villeurbanne, France

[2] Ecole Super Chim Phys & Elect, F-69622 Villeurbanne, France

[3] Rice Univ, Dept Chem, Houston, TX 77005 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 27期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

indole; oxazolines; cyclization; oxidation; hypervalent iodine;

D O I：

10.1016/S0040-4039(99)00872-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel oxidation of indolic 2-oxazolines with iodobenzene diacetate leads to unusual spiroheterocycles of potential interest in synthetic and medicinal chemistry. In several instances, addition of 2,2,2-trifluoroethanol (the solvent for such oxidations) to the substrates was observed. (C) 1999 Elsevier Science Ltd, All rights reserved.

引用

收藏

页码：4985 / 4988

页数：4

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