Gangliosides are the binding substances in neural cells for tetanus and botulinum toxins in mice

被引：87

作者：

Kitamura, M

Takamiya, K

Aizawa, S

Furukawa, K

机构：

[1] Natl Inst Infect Dis, Dept Bacteriol, Lab Bacterial Toxins, Shinjuku Ku, Tokyo 1628640, Japan

[2] Osaka Univ, Sch Med, Dept Neurochem, Osaka 5650871, Japan

[3] Kumamoto Univ, Sch Med, Inst Mol Embryol & Genet, Dept Morphogenesis, Kumamoto 8600811, Japan

[4] Nagoya Univ, Sch Med, Dept Biochem 2, Showa Ku, Nagoya, Aichi 466, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 1999年 / 1441卷 / 01期

关键词：

tetanus; botulinum; toxin; ganglioside; knockout mouse;

D O I：

10.1016/S1388-1981(99)00140-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We used the knockout mice lacking gangliosides and evaluated their response to tetanus and botulinum toxins. We found that tetanus toxin and botulinum type A or B toxin was less toxic in the knockout mice. We conclude that the toxins bind to the gangliosides on the synapses in the initial step of intoxication prior to penetration of the toxins into the neural cells. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 3

页数：3

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[3]

HARBERMANN E, 1986, CURR TOP MICROBIOL I, V129, P93

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