Treatment of Serious Calcium Channel Blocker Overdose With Levosimendan, a Calcium Sensitizer

被引：29

作者：

Varpula, Tero ^{[1
]}

Rapola, Janne ^{[2
]}

Sallisalmi, Marko

Kurola, Jouni ^{[3
]}

机构：

[1] Helsinki Univ Hosp, Jorvi Hosp, Dept Anesthesiol & Intens Care Med, Espoo 02740, Finland

[2] Helsinki Univ Hosp, Dept Cardiol, Helsinki, Finland

[3] Kuopio Univ Hosp, Intens Care Unit, SF-70210 Kuopio, Finland

来源：

ANESTHESIA AND ANALGESIA | 2009年 / 108卷 / 03期

关键词：

TROPONIN-C; MANAGEMENT; VERAPAMIL; FAILURE; CPR;

D O I：

10.1213/ane.0b013e3181931737

中图分类号：

R614 [麻醉学];

学科分类号：

100217 [麻醉学];

摘要：

Calcium channel blocker (CCB) overdose is often lethal. Conventional medical treatment includes IV calcium, high doses of catecholamines, insulin, and glucagon. A new inotropic drug, levosimendan, should be considered in severe CCB poisoning. Levosimendan's pharmacologic features differ from other inotropic drugs. It is a calcium sensitizer and improves contraction without increasing intracytosolic calcium concentration. We describe two patients with serious CCB overdose. Despite intensive medical and mechanical cardiovascular support, both patients remained in shock. Hemodynamics gradually improved after administration of levosimendan.

引用

页码：790 / 792

页数：3

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