HLA-G: a shield against inflammatory aggression

被引：163

作者：

Carosella, ED ^{[1
]}

Moreau, P ^{[1
]}

Aractingi, S ^{[1
]}

Rouas-Freiss, N ^{[1
]}

机构：

[1] Hop St Louis, Inst Univ Hematol, CEA, DSV,DRM,Serv Rech Hematoimmunol, F-75010 Paris, France

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 10期

关键词：

D O I：

10.1016/S1471-4906(01)02007-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent developments in the field of HLA-G research have revealed that, besides its involvement during pregnancy, HLA-G is expressed in peripheral tissues during pathological processes, such as viral infections, malignancies and organ transplantation. Here, we discuss recent findings regarding the influence of HLA-G on the T helper (Th) cytokine balance (favoring Th2-type responses), and the expression of HLA-G during chronic, cutaneous inflammatory diseases, such as psoriasis and atopic dermatitis. We propose a novel role for HLA-G as a tissue-protective molecule in inflammatory responses.

引用

页码：553 / 555

页数：3

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