p53 phosphorylation in mouse skin and in vitro human skin model by high-dose-radiation exposure

被引:11
作者
Koike, M
Sugasawa, J
Koike, A
Kohno, Y
机构
[1] Natl Inst Radiol Sci, Radiat Hazards Res Grp, Inage Ku, Chiba 2638555, Japan
[2] Showa Univ, Sch Dent, Tokyo, Japan
关键词
ATM; DNA-PKcs; p53; skin; X-ray;
D O I
10.1269/jrr.46.461
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The skin is an external organ that is most frequently exposed to radiation. High-dose radiation initiates and promotes acute radiation injury. Thus, it is important to investigate the influence of high-dose radiation exposure on the skin at the molecular level. The post-translational modification of p53 plays a central role in radiation responses, including apoptosis and cell growth arrest. Although it is well known that ataxia telangiectasia mutated (ATM) kinase and DNA-dependent protein kinase (DNA-PK) can phosphorylate Ser15/Ser18 of p53 in vitro, the post-translational modification pattern and the modifier of p53 in the skin after exposure to high-dose X-rays are not yet well understood. Here we show that the phosphorylation of p53 on Ser15/Ser18, as well as the phosphorylation of histone H2AX on Ser139, was detected in the keratinocytes of the mouse skin and human skin models after high-dose X-ray irradiation. Following high-dose X-ray irradiation, both proteins were also phosphorylated in the skin keratinocytes of both ATM gene knockout mice and DNA-PK-deficient SCID mice.
引用
收藏
页码:461 / 468
页数:8
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