IgA antibodies to gliadin and coeliac disease in psoriatic arthritis

被引:57
作者
Lindqvist, U [1 ]
Rudsander, Å [1 ]
Boström, Å [1 ]
Nilsson, B [1 ]
Michaëlsson, G [1 ]
机构
[1] Univ Uppsala Hosp, Dept Med Sci, S-75185 Uppsala, Sweden
关键词
Crohn's disease; ulcerative colitis; endomysium antibodies; autoimmune thyroid disease; concomitant diseases;
D O I
10.1093/rheumatology/41.1.31
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives. To find out whether patients with psoriatic arthritis (PsoA) have an increased prevalence of antibodies to gliadin (AGA) and of coeliac disease. Methods. One hundred and fourteen PsoA patients with skin disease of 20+/-13 yr and joint disease of 11+/-10 yr duration answered a questionnaire concerning their medical history and underwent clinical examination, including radiology. Serum IgA AGA and IgG AGA, IgA antibodies to endomysium and immunoglobulins, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) concentration were determined. Results. Five of the 114 patients (4.4%) had coeliac disease. After exclusion of these five patients, the mean IgA AGA concentration was significantly higher (P=0.0005) than that in a reference group. None of the patients had IgA antibodies to endomysium. The mean serum IgA concentration was significantly increased and IgM decreased. Patients with a high concentration of IgA AGA had significantly higher ESR and CRP and a longer duration of morning stiffness than those with a low AGA concentration. Conclusions. Patients with PsoA have an increased prevalence of raised serum IgA AGA and of coeliac disease. Patients with raised IgA AGA seem to have more pronounced inflammation than those with a low IgA AGA concentration.
引用
收藏
页码:31 / 37
页数:7
相关论文
共 32 条
[1]   Antibodies to cytokeratins in inflammatory arthropathies [J].
Borg, AA .
SEMINARS IN ARTHRITIS AND RHEUMATISM, 1997, 27 (03) :186-195
[2]   ARTHRITIS AND CELIAC-DISEASE [J].
BOURNE, JT ;
KUMAR, P ;
HUSKISSON, EC ;
MAGEED, R ;
UNSWORTH, DJ ;
WOJTULEWSKI, JA .
ANNALS OF THE RHEUMATIC DISEASES, 1985, 44 (09) :592-598
[3]   CELIAC-DISEASE - ASSOCIATED DISORDERS AND SURVIVAL [J].
COLLIN, P ;
REUNALA, T ;
PUKKALA, E ;
LAIPPALA, P ;
KEYRILAINEN, O ;
PASTERNACK, A .
GUT, 1994, 35 (09) :1215-1218
[4]  
COTAFAVA F, 1991, PEDIAT MED CHIR, V13, P431
[5]   THE EUROPEAN-SPONDYLARTHROPATHY-STUDY-GROUP PRELIMINARY CRITERIA FOR THE CLASSIFICATION OF SPONDYLARTHROPATHY [J].
DOUGADOS, M ;
VANDERLINDEN, S ;
JUHLIN, R ;
HUITFELDT, B ;
AMOR, B ;
CALIN, A ;
CATS, A ;
DIJKMANS, B ;
OLIVIERI, I ;
PASERO, G ;
VEYS, E ;
ZEIDLER, H .
ARTHRITIS AND RHEUMATISM, 1991, 34 (10) :1218-1227
[6]  
Eriksson MO, 1998, BRIT J DERMATOL, V138, P390
[7]  
Feighery C, 1998, EUR J GASTROEN HEPAT, V10, P919
[8]   SEVERE PSORIASIS - ORAL THERAPY WITH A NEW RETINOID [J].
FREDRIKSSON, T ;
PETTERSSON, U .
DERMATOLOGICA, 1978, 157 (04) :238-244
[9]  
GRODZINSKY E, 1992, ANN ALLERGY, V69, P66
[10]   PRESENCE OF IGA AND IGG ANTIGLIADIN ANTIBODIES IN HEALTHY-ADULTS AS MEASURED BY MICRO-ELISA - EFFECT OF VARIOUS CUTOFF LEVELS ON SPECIFICITY AND SENSITIVITY WHEN DIAGNOSING CELIAC-DISEASE [J].
GRODZINSKY, E ;
HED, J ;
LIEDEN, G ;
SJOGREN, F ;
STROM, M .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1990, 92 (02) :119-123