Renal Allograft Recipients Fail to Increase Interferon-γ During Invasive Fungal Diseases

被引：14

作者：

Armstrong-James, D. ^{[1
]}

Teo, I. ^{[1
]}

Herbst, S. ^{[1
]}

Petrou, M. ^{[1
]}

Shiu, K. Y. ^{[2
]}

McLean, A. ^{[3
]}

Taube, D. ^{[3
]}

Dorling, A. ^{[2
]}

Shaunak, S. ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sect Infect Dis & Immun, Dept Med, London, England

[2] Kings Coll London, MRC Ctr Transplantat, Guys Hosp, London WC2R 2LS, England

[3] Imperial Coll Healthcare NHS Trust, London, England

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2012年 / 12卷 / 12期

关键词：

Cytokines; diagnosis; interferon-gamma; invasive fungal disease; renal allograft; TRANSPLANT PATIENTS; INFECTIONS; POLYMORPHISM;

D O I：

10.1111/j.1600-6143.2012.04254.x

中图分类号：

R61 [外科手术学];

学科分类号：

100210 [外科学];

摘要：

Invasive fungal diseases are a major cause of death in renal allograft recipients. We previously reported that adjunctive recombinant human interferon-? therapy has clinical utility for invasive fungal diseases after renal transplantation. We have now developed a rapid peripheral blood-based quantitative real-time PCR assay that enables accurate profiling of cytokine imbalances. Our preliminary studies in renal transplant patients with invasive fungal diseases suggest that they fail to mount an adequate interferon-? response to the fungal infection. In addition, they have reduced IL-10 and increased TNF-a when compared to stable renal transplant patients. These preliminary cytokine profiling-based observations provide a possible explanation for the therapeutic benefit of adjunctive human interferon-? therapy in renal allograft recipients with invasive fungal diseases.

引用

页码：3437 / 3440

页数：4

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