Chemokines and chemokine receptors: role in HIV infection

被引：33

作者：

Kalinkovich, A ^{[1
]}

Weisman, Z ^{[1
]}

Bentwich, Z ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Kaplan Med Ctr, AIDS Ctr,R Ben Ari Inst Clin Immunol, IL-76100 Rehovot, Israel

来源：

IMMUNOLOGY LETTERS | 1999年 / 68卷 / 2-3期

关键词：

Africa; chemokine receptors; chemokines; HIV-1; susceptibility;

D O I：

10.1016/S0165-2478(99)00059-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Our understanding of the host factors that determine susceptibility and progression of HIV infection has been very limited. In particular, it has been not clear why some people remain uninfected being repeatedly exposed to HIV-1, and others who have been infected by HIV, remain clinically asymptomatic for long periods of time. Recently it has been demonstrated that mutated forms of a number of chemokine receptors that act as coreceptors for HIV-1 entry may account for some of these phenomena. Furthermore, chemokines such as RANTES and others, being the natural ligands for chemokine receptors, have been shown to be effective inhibitors of HIV-1 infection. In this review we discuss some of the genetic, immunological, virological and epidemiological data relevant to the very important role chemokines and chemokine receptors play in HIV pathogenesis with special reference to the increased susceptibility of the African host to HIV infection. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：281 / 287

页数：7

共 83 条

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