Simultaneous measurements of cerebral oxygenation changes during brain activation by near-infrared spectroscopy and functional magnetic resonance imaging in healthy young and elderly subjects

被引:204
作者
Mehagnoul-Schipper, DJ
van der Kallen, BFW
Colier, WNJM
van der Sluijs, MC
van Erning, LJTO
Thijssen, HOM
Oeseburg, B
Hoefnagels, WHL
Jansen, RWMM
机构
[1] Univ Nijmegen, Ctr Med, Dept Geriatr Med, NL-6500 HB Nijmegen, Netherlands
[2] Univ Nijmegen, Ctr Med, Dept Radiol, NL-6500 HB Nijmegen, Netherlands
[3] Univ Nijmegen, Ctr Med, Dept Physiol, NL-6500 HB Nijmegen, Netherlands
关键词
near infrared spectroscopy; magnetic resonance imaging; brain oxygenation; cerebrovascular circulation physiology; functional motor cortex activation; blood oxygen; aging;
D O I
10.1002/hbm.10026
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Near infrared spectroscopy (NIRS) and functional magnetic resonance imaging (fMRI) both allow non-invasive monitoring of cerebral cortical oxygenation responses to various stimuli. To compare these methods in elderly subjects and to determine the effect of age on cortical oxygenation responses, we determined motor-task-related changes in deoxyhemoglobin concentration ([HHb]) over the left motor cortex in six healthy young subjects (age 35 +/- 9 years, mean +/- SD) and five healthy elderly subjects (age 73 +/- 3 years) by NIRS and blood-oxygen-level-dependent (BOLD) fMRI simultaneously. The motor-task consisted of seven cycles of 20-sec periods of contralateral finger-tapping at a rate as fast as possible alternated with 40-sec periods of rest. Time-locked averages over the seven cycles were used for further analysis. Task-related decreases in [HHb] over the motor cortex were measured by NIRS, with maximum changes of -0.83 +/- 0.38 mumol/L (P < 0.01) for the young and -0.32 +/- 0.17 mu mol/L (P < 0.05) for the elderly subjects. The BOLD-fMRI signal increased over the cortex volume under investigation with NIRS, with maximum changes of 2.11 +/- 0.72% (P < 0.01) for the young and 1.75 +/- 0.71% (P < 0.01) for the elderly subjects. NIRS and BOLD-fMRI measurements showed good correlation in the young (r = -0.70, r(2) = 0.48, P < 0.001) and elderly subjects (r = -0.82, r(2) = 0.67, P < 0.001). Additionally, NIRS measurements demonstrated age-dependent decreases in task-related cerebral oxygenation responses (P < 0.05), whereas fMRI measurements demonstrated smaller areas of cortical activation in the elderly subjects (P < 0.05). These findings demonstrate that NIRS and fMRI similarly assess cortical oxygenation changes in young subjects and also in elderly subjects. In addition, cortical oxygenation responses to brain activation alter with aging.
引用
收藏
页码:14 / 23
页数:10
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