Change in Frailty and Risk of Death in Older Persons

被引：105

作者：

Buchman, A. S. ^{[1
,2
]}

Wilson, R. S. ^{[1
,2
,3
]}

Bienias, J. L. ^{[1
,4
,5
]}

Bennett, D. A. ^{[2
]}

机构：

[1] Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA

[2] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA

[3] Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA

[4] Rush Univ, Med Ctr, Rush Inst Healthy Aging, Chicago, IL 60612 USA

[5] Rush Univ, Med Ctr, Dept Internal Med, Chicago, IL 60612 USA

来源：

EXPERIMENTAL AGING RESEARCH | 2009年 / 35卷 / 01期

关键词：

WOMENS HEALTH; FUNCTIONAL DECLINE; ALZHEIMERS-DISEASE; PARKINSONIAN SIGNS; LONGITUDINAL DATA; DISABILITY; MORTALITY; ADULTS; COAGULATION; PERFORMANCE;

D O I：

10.1080/03610730802545051

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The authors developed and validated a continuous composite measure of frailty and examined its rate of change in 832 older persons with annual evaluations for up to 8 years. In generalized estimating equation models adjusted for age, sex, and education, there was a significant increase in frailty during follow-up. In a proportional hazards model controlling for age, sex, education, and baseline frailty, each 1-unit increase in annual change in frailty was associated with an almost 5 times the risk of mortality. Using a continuous measure, the authors document that frailty is progressive in some older persons and that its rate of progression is associated with mortality.

引用

页码：61 / 82

页数：22

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