Inhibition of Amyloid β Aggregation by Acteoside, a Phenylethanoid Glycoside

被引：72

作者：

Kurisu, Manami ^{[1
]}

Miyamae, Yusaku ^{[2
]}

Murakami, Kazuma ^{[3
]}

Han, Junkyu ^{[1
,4
]}

Isoda, Hiroko ^{[1
,4
]}

Irie, Kazuhiro ^{[3
]}

Shigemori, Hideyuki ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan

[2] Kyoto Univ, Grad Sch Biostudies, Sakyo Ku, Kyoto 6068502, Japan

[3] Kyoto Univ, Grad Sch Agr, Sakyo Ku, Kyoto 6068502, Japan

[4] Univ Tsukuba, Alliance Res North Africa, Tsukuba, Ibaraki 3058572, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 06期

关键词：

acteoside; amyloid beta; aggregation; Alzheimer's disease; phenylethanoid glycoside; CAFFEOYLQUINIC ACIDS; SH-SY5Y CELLS; PROTEIN; DISEASE;

D O I：

10.1271/bbb.130101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid beta protein (A beta 42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of A beta 42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.

引用

页码：1329 / 1332

页数：4

共 9 条

[1]

ALZHEIMERS-DISEASE - INITIAL REPORT OF THE PURIFICATION AND CHARACTERIZATION OF A NOVEL CEREBROVASCULAR AMYLOID PROTEIN [J].

GLENNER, GG ;

WONG, CW .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (03) :885-890

[2]

Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide [J].

Haass, Christian ;

Selkoe, Dennis J. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (02) :101-112

[3]

NEUROPROTECTIVE EFFECT OF 3,5-DI-O-CAFFEOYLQUINIC ACID ON SH-SY5Y CELLS AND SENESCENCE-ACCELERATED-PRONE MICE 8 THROUGH THE UP-REGULATION OF PHOSPHOGLYCERATE KINASE-1 [J].

Han, J. ;

Miyamae, Y. ;

Shigemori, H. ;

Isoda, H. .

NEUROSCIENCE, 2010, 169 (03) :1039-1045

[4]

AMYLOID PLAQUE CORE PROTEIN IN ALZHEIMER-DISEASE AND DOWN SYNDROME [J].

MASTERS, CL ;

SIMMS, G ;

WEINMAN, NA ;

MULTHAUP, G ;

MCDONALD, BL ;

BEYREUTHER, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (12) :4245-4249

[5]

Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein [J].

Miyamae, Yusaku ;

Kurisu, Manami ;

Murakami, Kazuma ;

Han, Junkyu ;

Isoda, Hiroko ;

Irie, Kazuhiro ;

Shigemori, Hideyuki .

BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (19) :5844-5849

[6]

3,4,5-tri-O-caffeoylquinic acid inhibits amyloid β-mediated cellular toxicity on SH-SY5Y cells through the upregulation of PGAM1 and G3PDH [J].

Miyamae, Yusaku ;

Han, Junkyu ;

Sasaki, Kazunori ;

Terakawa, Mika ;

Isoda, Hiroko ;

Shigemori, Hideyuki .

CYTOTECHNOLOGY, 2011, 63 (02) :191-200

[7]

Structure-Activity Relationship of Caffeoylquinic Acids on the Accelerating Activity on ATP Production [J].

Miyamae, Yusaku ;

Kurisu, Manami ;

Han, Junkyu ;

Isoda, Hiroko ;

Shigemori, Hideyuki .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (04) :502-507

[8]

Naiki H, 1999, METHOD ENZYMOL, V309, P305

[9]

Acteoside protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell injury [J].

Wang, Hongquan ;

Xu, Yuxia ;

Yan, Jie ;

Zhao, Xiaoyan ;

Sun, Xiaobo ;

Zhang, Yanping ;

Guo, Jingchun ;

Zhu, Cuiqing .

BRAIN RESEARCH, 2009, 1283 :139-147

← 1 →