Iron-regulated surface determinants (Isd) of Staphylococcus aureus:: stealing iron from heme

被引：177

作者：

Skaar, EP ^{[1
]}

Schneewind, O ^{[1
]}

机构：

[1] Univ Chicago, Cummings Life Sci Ctr, Committee Microbiol, Chicago, IL 60637 USA

来源：

MICROBES AND INFECTION | 2004年 / 6卷 / 04期

关键词：

Staphylococcus aureus; heme; hemoproteins; iron-regulated surface determinants; sortase; iron;

D O I：

10.1016/j.micinf.2003.12.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cell-wall sorted proteins of the Staphylococcus aureus iron-regulated surface determinant system bind human hemoproteins, remove the heme molecule, and transport heme through the cell wall and plasma membrane for accumulation in the bacterial cytoplasm. Once inside the cell, the porphyrin ring of heme is degraded by heme degrading monooxygenases, leading to the formation of free iron for use by the bacterium as a nutrient source. (C) 2004 Elsevier SAS. All rights reserved.

引用

页码：390 / 397

页数：8

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