Endometrial NK cells are special immature cells that await pregnancy

被引：203

作者：

Manaster, Irit ^{[1
]}

Mizrahi, Saar ^{[1
]}

Goldman-Wohl, Debra ^{[2
]}

Sela, Hen Y. ^{[3
]}

Stern-Ginossar, Noam ^{[1
]}

Lankry, Dikla ^{[1
]}

Gruda, Raizy ^{[1
]}

Hurwitz, Arye ^{[2
]}

Bdolah, Yuval ^{[2
]}

Haimov-Kochman, Ronit ^{[2
]}

Yagel, Simcha ^{[2
]}

Mandelboim, Ofer ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Lautenberg Ctr Gen & Tumor Immunol, BioMed Res Inst, IL-91010 Jerusalem, Israel

[2] Hadassah Univ Hosp Mt Scopus, Dept Obstet & Gynecol, Jerusalem, Israel

[3] Hadassah Hebrew Univ, Med Ctr, Dept Obstet & Gynecol, Jerusalem, Israel

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 181卷 / 03期

关键词：

D O I：

10.4049/jimmunol.181.3.1869

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NK cells populate the human endometrium before pregnancy. Unlike decidual NK cells that populate the decidua during pregnancy, the NK cells present in the human endometrium, before pregnancy, have not been fully characterized. In this study, we provide a detailed analysis of the origin, phenotype, and function of endometrial NK cells (eNK). We show that eNK cells have a unique receptor repertoire. In particular, they are negative for NKp30 and chemokine receptor expression, which distinguishes them from any other NK subset described so far. We further show that eNK cells lack NK-specific functional phenotype and activity such as cytokine secretion and cytotoxicity, before IL-15 stimulation. Following such stimulation, endometrial NK cells acquire phenotype and function that are similar to those of decidual NK cells. We therefore suggest that eNK cells are inactive cells (before IL-15 activation and in relation to the known NK activity) that are present in the endometrium before conception, waiting for pregnancy.

引用

页码：1869 / 1876

页数：8

共 48 条

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