Targeting of marrow-derived astrocytes to the ischemic brain

被引：123

作者：

Eglitis, MA

Dawson, D

Park, KW

Mouradian, MM

机构：

[1] NINDS, Genet Pharmacol Unit, Expt Therapeut Branch, NIH, Bethesda, MD 20892 USA

[2] NINDS, Stroke Branch, NIH, Bethesda, MD 20892 USA

来源：

NEUROREPORT | 1999年 / 10卷 / 06期

关键词：

astrocyte; bone marrow; brain; fluorescent in situ hybridization; ischemia; transplantation;

D O I：

10.1097/00001756-199904260-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

BONE marrow progenitor cells have been shown to contribute to a small proportion of cells in nonhematopoietic tissues including the brain. In the acute unilateral middle cerebral artery occlusion model in spontaneously hypertensive rats following male-to-female bone marrow transplantation, we present data suggesting that 55% more marrow-derived cells, in general, and 161% more GFAP-positive astrocytes, in particular, migrate preferentially to the ischemic cortex than to the contralateral non-ischemic hemisphere. In addition to their biological significance, our findings could have therapeutic implications. Marrow-derived progenitor cells could potentially be used as vehicles for ex vivo gene transfer to the brain.

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收藏

页码：1289 / 1292

页数：4

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