Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin

被引:92
作者
deLecea, L
RuizLozano, P
Danielson, PE
PeelleKirley, J
Foye, PE
Frankel, WN
Sutcliffe, JG
机构
[1] SCRIPPS RES INST, DEPT BIOL MOL, LA JOLLA, CA 92037 USA
[2] UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA
[3] JACKSON LAB, BAR HARBOR, ME 04609 USA
关键词
D O I
10.1006/geno.1997.4763
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Cortistatin is a 14-residue putative neuropeptide with strong structural similarity to somatostatin and is expressed predominantly in cortical GABAergic interneurons of rats. Administration of cortistatin into the brain ventricles specifically enhances slow-wave sleep, presumably by antagonizing the effects of acetylcholine on cortical excitability. Here we report the identification of cDNAs corresponding to mouse and human preprocortistatin and the mRNA distribution and gene mapping of mouse cortistatin. Analysis of the nucleotide and predicted amino acid sequences from rat and mouse reveals that the 14 C-terminal residues of preprocortistatin, which make up the sequence that is most similar to somatostatin, are conserved between species. Lack of conservation of other dibasic amino acid residues whose cleavage by prohormone convertases would give rise to additional peptides suggests that cortistatin-14 is the only active peptide derived from the precursor. As in the rat, mouse preprocortistatin mRNA is present in GABAergic interneurons in the cerebral cortex and hippocampus. The preprocortistatin gene maps to mouse chromosome 4, in a region showing conserved synteny with human 1p36. The human putative cortistatin peptide has an arginine for lysine substitution, compared to the rat and mouse products, and is N-terminally extended by 3 amino acids. (C) 1997 Academic Press.
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页码:499 / 506
页数:8
相关论文
共 21 条
[1]   GALANIN IMMUNOREACTIVITY WITHIN THE PRIMATE BASAL FOREBRAIN - EVOLUTIONARY CHANGE BETWEEN MONKEYS AND APES [J].
BENZING, WC ;
KORDOWER, JH ;
MUFSON, EJ .
JOURNAL OF COMPARATIVE NEUROLOGY, 1993, 336 (01) :31-39
[2]   TOPOGRAPHICAL DISPLACEMENT OF NEUROPEPTIDE-PRODUCING NUCLEI AS AN INDICATOR OF EVOLUTIONARY BRAIN-DEVELOPMENT [J].
BLAHSER, S .
PROGRESS IN BRAIN RESEARCH, 1992, 92 :187-199
[3]   MOLECULAR-BASIS OF MYOTONIC-DYSTROPHY - EXPANSION OF A TRINUCLEOTIDE (CTG) REPEAT AT THE 3' END OF A TRANSCRIPT ENCODING A PROTEIN-KINASE FAMILY MEMBER [J].
BROOK, JD ;
MCCURRACH, ME ;
HARLEY, HG ;
BUCKLER, AJ ;
CHURCH, D ;
ABURATANI, H ;
HUNTER, K ;
STANTON, VP ;
THIRION, JP ;
HUDSON, T ;
SOHN, R ;
ZEMELMAN, B ;
SNELL, RG ;
RUNDLE, SA ;
CROW, S ;
DAVIES, J ;
SHELBOURNE, P ;
BUXTON, J ;
JONES, C ;
JUVONEN, V ;
JOHNSON, K ;
HARPER, PS ;
SHAW, DJ ;
HOUSMAN, DE .
CELL, 1992, 68 (04) :799-808
[4]   4 STRUCTURALLY DISTINCT NEURON-SPECIFIC OLFACTOMEDIN-RELATED GLYCOPROTEINS PRODUCED BY DIFFERENTIAL PROMOTER UTILIZATION AND ALTERNATIVE MESSENGER-RNA SPLICING FROM A SINGLE-GENE [J].
DANIELSON, PE ;
FORSSPETTER, S ;
BATTENBERG, ELF ;
DELECEA, L ;
BLOOM, FE ;
SUTCLIFFE, JG .
JOURNAL OF NEUROSCIENCE RESEARCH, 1994, 38 (04) :468-478
[5]   P1B15 - A CDNA CLONE OF THE RAT MESSENGER-RNA ENCODING CYCLOPHILIN [J].
DANIELSON, PE ;
FORSSPETTER, S ;
BROW, MA ;
CALAVETTA, L ;
DOUGLASS, J ;
MILNER, RJ ;
SUTCLIFFE, JG .
DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1988, 7 (04) :261-267
[6]   TRANSCRIPTS ENCODING A NEURAL MEMBRANE CD26 PEPTIDASE-LIKE PROTEIN ARE STIMULATED BY SYNAPTIC ACTIVITY [J].
DELECEA, L ;
SORIANO, E ;
CRIADO, JR ;
STEFFENSEN, SC ;
HENRIKSEN, SJ ;
SUTCLIFFE, JG .
MOLECULAR BRAIN RESEARCH, 1994, 25 (3-4) :286-296
[7]   A cortical neuropeptide with neuronal depressant and sleep-modulating properties [J].
deLecea, L ;
Criado, JR ;
ProsperoGarcia, O ;
Gautvik, KM ;
Schweitzer, P ;
Danielson, PE ;
Dunlop, CLM ;
Siggins, GR ;
Henriksen, SJ ;
Sutcliffe, JG .
NATURE, 1996, 381 (6579) :242-245
[8]  
DIETRICH W, 1992, GENETICS, V131, P423
[9]   CARBOXYPEPTIDASE-E [J].
FRICKER, LD .
ANNUAL REVIEW OF PHYSIOLOGY, 1988, 50 :309-321
[10]   MAPPING POLYPEPTIDE HORMONE GENES IN THE MOUSE - SOMATOSTATIN, GLUCAGON, CALCITONIN, AND PARATHYROID-HORMONE [J].
LALLEY, PA ;
SAKAGUCHI, AY ;
EDDY, RL ;
HONEY, NH ;
BELL, GI ;
SHEN, LP ;
RUTTER, WJ ;
JACOBS, JW ;
HEINRICH, G ;
CHIN, WW ;
NAYLOR, SL .
CYTOGENETICS AND CELL GENETICS, 1987, 44 (2-3) :92-97