22q11 deletion syndrome in childhood onset schizophrenia: an update

被引：66

作者：

Sporn, A

Addington, A

Reiss, AL

Dean, M

Gogtay, N

Potocnik, U

Greenstein, D

Hallmayer, J

Gochman, P

Lenane, M

Baker, N

Tossell, J

Rapoport, JL

机构：

[1] NIMH, Child Psychiat Branch, Bethesda, MD 20892 USA

[2] Stanford Univ, Sch Med, Dept Psychiat, Stanford, CA 94305 USA

[3] NCI, Lab Genom Divers, Frederick, MD 21701 USA

来源：

MOLECULAR PSYCHIATRY | 2004年 / 9卷 / 03期

关键词：

D O I：

10.1038/sj.mp.4001477

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spontaneous deletion of a small part of chromosome 22 is associated with risk for schizophrenia. The authors update previous reports on 22q11 deletion in childhood onset schizophrenia. Rate of 22q11 deletion in childhood schizophrenia was 5.3%, much higher than 0.46% found for adult onset. Patients with and without deletion did not differ with respect to severity of illness, age of onset or brain imaging data. The 22q11 deletion and perhaps other cytogenetic abnormalities are more prevalent in the childhood onset disorder.

引用

页码：225 / 226

页数：2

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