Exploring a chemical encoding strategy for combinatorial synthesis using Friedel-Crafts alkylation

被引：5

作者：

Scott, RH ^{[1
]}

Barnes, C ^{[1
]}

Gerhard, U ^{[1
]}

Balasubramanian, S ^{[1
]}

机构：

[1] Univ Cambridge, Chem Lab, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 14期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/a902489a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of scandium(III) triflate and ytterbium(III) triflate-catalysed Friedel-Crafts alkylation to insert a set of hydroxymethyl pyrrole amide tags (1b-i) on to polystyrene resins under mild conditions and the encoding of a split and mix peptide library is demonstrated.

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收藏

页码：1331 / 1332

页数：2

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