Selenylation modification can enhance immune-enhancing activity of Chinese angelica polysaccharide

被引：115

作者：

Qin, Tao ^{[1
]}

Chen, Jin ^{[2
]}

Wang, Deyun ^{[1
]}

Hu, Yuanliang ^{[1
]}

Zhang, Jing ^{[1
]}

Wang, Mi ^{[1
]}

Qiu, Shulei ^{[1
]}

Gao, Zhenzhen ^{[1
]}

Liu, Rongrong ^{[1
]}

Yu, Yun ^{[1
]}

Huang, Yee ^{[1
]}

Wang, Qiaochu ^{[3
]}

Wang, Qiaoxiu ^{[1
]}

机构：

[1] Nanjing Agr Univ, Inst Tradit Chinese Vet Med, Coll Vet Med, Nanjing 210095, Jiangsu, Peoples R China

[2] Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing 210014, Peoples R China

[3] Nanjing Med Univ, Sch Basic Med Sci, Dept Biotechnol, Nanjing 210029, Jiangsu, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2013年 / 95卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Selenizing Chinese angelica polysaccharide (sCAP); Lymphocyte proliferation; Antibody titer; IFN-gamma; IL-6; HERBAL MEDICINAL INGREDIENTS; SULFATED POLYSACCHARIDES; CHICKEN; VACCINATION; PROFILES; DISEASE;

D O I：

10.1016/j.carbpol.2013.02.072

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

On the basis of previous test that selenizing Chinese angelica polysaccharides (sCAPs) with stronger immune-enhancing activity in vitro were picked out, the immune-enhancing activity in vivo of three sCAPs, sCAP(2), sCAP(6) and sCAP(8), at high and low dosage were compared taking the unmodified Chinese angelica polysaccharide (CAP) as control by determination of peripheral lymphocyte proliferation, serum antibody titer, IFN-gamma and IL-6 contents in chicken vaccinated with Newcastle Disease vaccine. The results showed that three sCAPs at suitable dosage could significantly promote lymphocyte proliferation, enhance serum antibody titer, IFN-gamma and IL-6 contents as compared with unmodified CAP, sCAP(2) at low dosage possessed the strongest action. These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of CAP, sCAP(2) possessed the best efficacy and would be as a component drug of new-type immunoenhancer. (c) 2013 Elsevier Ltd. All rights reserved.

引用

页码：183 / 187

页数：5

共 30 条

[1]

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