Receptors for laminins during epithelial morphogenesis

被引:79
作者
Ekblom, P
机构
[1] Department of Animal Physiology, Uppsala University, Biomedical Center, S-75124 Uppsala
关键词
D O I
10.1016/S0955-0674(96)80112-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Laminin-1 is expressed by many embryonic epithelial cell types. It binds to receptors on the epithelial cell surface. The integrin alpha 6 beta 1 is a well known laminin-1 receptor that is expressed on many embryonic epithelial cells. More recently, dystroglycan was discovered as a high-affinity receptor for laminin-1 and laminin-2. It is expressed not only by muscle cells but also by embryonic epithelial cells. In embryonic epithelia, dystroglycan may act by binding to the E3 fragment of laminin-1. Integrins and the dystroglycan complex seem to be important for epithelial morphogenesis, but the relative roles of these two receptor systems for epithelial cells are still unclear.
引用
收藏
页码:700 / 706
页数:7
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