RETRACTED: Genetic tracing reveals a stereotyped sensory map in the olfactory cortex (Retracted Article. See vol 452, pg 120, 2008)

被引:173
作者
Zou, ZH
Horowitz, LF
Montmayeur, JP
Snapper, S
Buck, LB [1 ]
机构
[1] Harvard Univ, Sch Med, Dept Neurobiol, Howard Hughes Med Inst, Boston, MA 02115 USA
[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Dept Med,Med Serv,Gastrointestinal Unit, Boston, MA 02114 USA
关键词
D O I
10.1038/35102506
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The olfactory system translates myriad chemical structures into diverse odour perceptions. To gain insight into how this is accomplished, we prepared mice that coexpressed a transneuronal tracer with only one of about 1,000 different odorant receptors. The tracer travelled from nasal neurons expressing that receptor to the olfactory bulb and then to the olfactory cortex, allowing visualization of cortical neurons that receive input from a particular odorant receptor. These studies revealed a stereotyped sensory map in the olfactory cortex in which signals from a particular receptor are targeted to specific clusters of neurons. Inputs from different receptors overlap spatially and could be combined in single neurons, potentially allowing for an integration of the components of an odorant's combinatorial receptor code. Signals from the same receptor are targeted to multiple olfactory cortical areas, permitting the parallel, and perhaps differential, processing of inputs from a single receptor before delivery to the neocortex and limbic system.
引用
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页码:173 / 179
页数:7
相关论文
共 48 条
[2]  
AMSTRONG W, 1995, RAT NERVOUS SYSTEM, P377
[3]  
[Anonymous], 1998, SYNAPTIC ORG BRAIN
[4]   The molecular receptive range of an odorant receptor [J].
Araneda, RC ;
Kini, AD ;
Firestein, S .
NATURE NEUROSCIENCE, 2000, 3 (12) :1248-1255
[5]  
Ausubel F.M., 2000, CURRENT PROTOCOLS MO
[6]   A NOVEL MULTIGENE FAMILY MAY ENCODE ODORANT RECEPTORS - A MOLECULAR-BASIS FOR ODOR RECOGNITION [J].
BUCK, L ;
AXEL, R .
CELL, 1991, 65 (01) :175-187
[7]   The molecular architecture of odor and pheromone sensing in mammals [J].
Buck, LB .
CELL, 2000, 100 (06) :611-618
[8]   Information coding in the vertebrate olfactory system. [J].
Buck, LB .
ANNUAL REVIEW OF NEUROSCIENCE, 1996, 19 :517-544
[9]   THE PROJECTIONS OF MITRAL CELLS FROM SMALL LOCAL REGIONS OF THE OLFACTORY-BULB - AN ANTEROGRADE TRACING STUDY USING PHA-L (PHASEOLUS-VULGARIS LEUKOAGGLUTININ) [J].
BUONVISO, N ;
REVIAL, MF ;
JOURDAN, F .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1991, 3 (06) :493-500
[10]  
Cote S, 1993, IMMUNOHISTOCHEMISTRY, P147