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Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic Bcl-2 gene

被引：17
作者：
Bilbao, G
Contreras, JL
Zhang, HG
Pike, MJ
Overturf, K
Mikheeva, G
Krasnykh, V
Curiel, DT
机构：
[1] Univ Alabama Birmingham, Gene Therapy Ctr, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Transplant Ctr, Dept Surg, Birmingham, AL 35294 USA
[3] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
[4] Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA
来源：
JOURNAL OF VIROLOGY | 1999年 / 73卷 / 08期
关键词：
D O I：
10.1128/JVI.73.8.6992-7000.1999
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.
引用
收藏
页码：6992 / 7000
页数：9
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