Neuroprotection is unlikely to be effective in humans using current trial designs

被引：87

作者：

Grotta, J ^{[1
]}

机构：

[1] Univ Texas, Houston Sch Med, Dept Neurol, Houston, TX 77030 USA

来源：

STROKE | 2002年 / 33卷 / 01期

关键词：

animal models; clinical trials; neuroprotection; stroke assessment;

D O I：

10.1161/str.33.1.306

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

引用

页码：306 / 307

页数：2

共 7 条

[1] Generalized efficacy of t-PA for acute stroke - Subgroup analysis of the NINDS t-PA stroke trial [J].

Brott, T ;

Broderick, J ;

Kothari, R ;

ODonoghue, M ;

Barsan, W ;

Tomsick, T ;

Spilker, J ;

Miller, R ;

Sauerbeck, L ;

Farrell, J ;

Kelly, J ;

Perkins, T ;

Miller, R ;

McDonald, T ;

Rorick, M ;

Hickey, C ;

Armitage, J ;

Perry, C ;

Thalinger, K ;

Rhude, R ;

Schill, J ;

Becker, PS ;

Heath, RS ;

Adams, D ;

Reed, R ;

Klei, M ;

Hughes, A ;

Anthony, J ;

Baudendistel, D ;

Zadicoff, C ;

Rymer, M ;

Bettinger, I ;

Laubinger, P ;

Schmerler, M ;

Meiros, G ;

Lyden, P ;

Dunford, J ;

Zivin, J ;

Rapp, K ;

Babcock, T ;

Daum, P ;

Persona, D ;

Brody, M ;

Jackson, C ;

Lewis, S ;

Liss, J ;

Mahdavi, Z ;

Rothrock, J ;

Tom, T ;

Zweifler, R .

STROKE, 1997, 28 (11) :2119-2125

[2] Intra-arterial prourokinase for acute ischemic stroke - The PROACT II study: A randomized controlled trial [J].

Furlan, A ;

Higashida, R ;

Wechsler, L ;

Gent, M ;

Rowley, H ;

Kase, C ;

Pessin, M ;

Ahuja, A ;

Callahan, F ;

Clark, WM ;

Silver, F ;

Rivera, F .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (21) :2003-2011

[3] Combination therapy stroke trial: Recombinant tissue-type plasminogen activator with/without lubeluzole [J].

Grotta, J .

CEREBROVASCULAR DISEASES, 2001, 12 (03) :258-263

[4]

HACKE W, 1995, JAMA-J AM MED ASSOC, V274, P1017, DOI 10.1001/jama.274.13.1017

[5] TEMPORAL THRESHOLDS FOR NEOCORTICAL INFARCTION IN RATS SUBJECTED TO REVERSIBLE FOCAL CEREBRAL-ISCHEMIA [J].

KAPLAN, B ;

BRINT, S ;

TANABE, J ;

JACEWICZ, M ;

WANG, XJ ;

PULSINELLI, W .

STROKE, 1991, 22 (08) :1032-1039

[6] TISSUE-PLASMINOGEN ACTIVATOR FOR ACUTE ISCHEMIC STROKE [J].

MARLER, JR ;

BROTT, T ;

BRODERICK, J ;

KOTHARI, R ;

ODONOGHUE, M ;

BARSAN, W ;

TOMSICK, T ;

SPILKER, J ;

MILLER, R ;

SAUERBECK, L ;

JARRELL, J ;

KELLY, J ;

PERKINS, T ;

MCDONALD, T ;

RORICK, M ;

HICKEY, C ;

ARMITAGE, J ;

PERRY, C ;

THALINGER, K ;

RHUDE, R ;

SCHILL, J ;

BECKER, PS ;

HEATH, RS ;

ADAMS, D ;

REED, R ;

KLEI, M ;

HUGHES, S ;

ANTHONY, J ;

BAUDENDISTEL, D ;

ZADICOFF, C ;

RYMER, M ;

BETTINGER, I ;

LAUBINGER, P ;

SCHMERLER, M ;

MEIROSE, G ;

LYDEN, P ;

RAPP, K ;

BABCOCK, T ;

DAUM, P ;

PERSONA, D ;

BRODY, M ;

JACKSON, C ;

LEWIS, S ;

LISS, J ;

MAHDAVI, Z ;

ROTHROCK, J ;

TOM, T ;

ZWEIFLER, R ;

DUNFORD, J ;

ZIVIN, J .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (24) :1581-1587

[7] Intravenous ancrod for treatment of acute ischemic stroke - The STAT study: A randomized controlled trial [J].

Sherman, DG ;

Atkinson, RP ;

Chippendale, T ;

Levin, KA ;

Ng, K ;

Futrell, N ;

Hsu, CY ;

Levy, DE .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (18) :2395-2403

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