MYC - TIMELINE Reflecting on 25 years with MYC

被引:1217
作者
Meyer, Natalie [2 ]
Penn, Linda Z. [1 ]
机构
[1] Ontario Canc Inst, Div Canc Genom & Prote, Toronto, ON M5G 2M9, Canada
[2] Amgen Canada Inc, Mississauga, ON L5N 7Y2, Canada
关键词
D O I
10.1038/nrc2231
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was identified. Since that time, MYC research has been intense and the advances impressive. On reflection, it is astonishing how each incremental insight into MYC regulation and function has also had an impact on numerous biological disciplines, including our understanding of molecular oncogenesis in general. Here we chronicle the major advances in our understanding of MYC biology, and peer into the future of MYC research.
引用
收藏
页码:976 / 990
页数:15
相关论文
共 293 条
[1]   NUCLEAR LOCATION OF THE PUTATIVE TRANSFORMING PROTEIN OF AVIAN MYELOCYTOMATOSIS VIRUS [J].
ABRAMS, HD ;
ROHRSCHNEIDER, LR ;
EISENMAN, RN .
CELL, 1982, 29 (02) :427-439
[2]   c-Myc is necessary for DNA damage-induced apoptosis in the G2 phase of the cell cycle [J].
Adachi, S ;
Obaya, AJ ;
Han, ZY ;
Ramos-Desimone, N ;
Wyche, JH ;
Sedivy, JM .
MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (15) :4929-4937
[3]   THE C-MYC ONCOGENE DRIVEN BY IMMUNOGLOBULIN ENHANCERS INDUCES LYMPHOID MALIGNANCY IN TRANSGENIC MICE [J].
ADAMS, JM ;
HARRIS, AW ;
PINKERT, CA ;
CORCORAN, LM ;
ALEXANDER, WS ;
CORY, S ;
PALMITER, RD ;
BRINSTER, RL .
NATURE, 1985, 318 (6046) :533-538
[4]   Transcriptional regulation and transformation by MYC proteins [J].
Adhikary, S ;
Eilers, M .
NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (08) :635-645
[5]   The ubiquitin ligase HectH9 regulates transcriptional activation by myc and is essential for tumor cell proliferation [J].
Adhikary, S ;
Marinoni, F ;
Hock, A ;
Hulleman, E ;
Popov, N ;
Beier, R ;
Bernard, S ;
Quarto, M ;
Capra, M ;
Goettig, S ;
Kogel, U ;
Scheffner, M ;
Helin, K ;
Eilers, M .
CELL, 2005, 123 (03) :409-421
[6]   Genetic regulators of large-scale transcriptional signatures in cancer [J].
Adler, AS ;
Lin, MH ;
Horlings, H ;
Nuyten, DSA ;
van de Vijver, MJ ;
Chang, HY .
NATURE GENETICS, 2006, 38 (04) :421-430
[7]   DIFFERENTIAL COMPLEMENTATION OF BCR-ABL POINT MUTANTS WITH C-MYC [J].
AFAR, DEH ;
GOGA, A ;
MCLAUGHLIN, J ;
WITTE, ON ;
SAWYERS, CL .
SCIENCE, 1994, 264 (5157) :424-426
[8]   HOMOGENEOUSLY STAINING CHROMOSOMAL REGIONS CONTAIN AMPLIFIED COPIES OF AN ABUNDANTLY EXPRESSED CELLULAR ONCOGENE (C-MYC) IN MALIGNANT NEUROENDOCRINE CELLS FROM A HUMAN-COLON CARCINOMA [J].
ALITALO, K ;
SCHWAB, M ;
LIN, CC ;
VARMUS, HE ;
BISHOP, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (06) :1707-1711
[9]   Mdm2 haplo-insufficiency profoundly inhibits Myc-induced lymphomagenesis [J].
Alt, JR ;
Greiner, TC ;
Cleveland, JL ;
Eischen, CM .
EMBO JOURNAL, 2003, 22 (06) :1442-1450
[10]   ONCOGENIC ACTIVITY OF THE C-MYC PROTEIN REQUIRES DIMERIZATION WITH MAX [J].
AMATI, B ;
BROOKS, MW ;
LEVY, N ;
LITTLEWOOD, TD ;
EVAN, GI ;
LAND, H .
CELL, 1993, 72 (02) :233-245