Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS

被引：62

作者：

Makoff, A

Pilling, C

Harrington, K

Emson, P

机构：

[1] WELLCOME FDN LTD,DIV BIOL,BECKENHAM BR3 3BS,KENT,ENGLAND

[2] BABRAHAM INST,DEPT NEUROBIOL,MRC,MOLEC NEUROSCI GRP,CAMBRIDGE CB2 4AT,ENGLAND

来源：

MOLECULAR BRAIN RESEARCH | 1996年 / 40卷 / 01期

关键词：

metabotropic glutamate receptor; G-protein; hybridization; in-situ; hippocampus; human polymorphism;

D O I：

10.1016/0169-328X(96)00110-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human metabotropic glutamate receptor type 7 (mGluR7) cDNA clones were isolated from a medulla cDNA library. The sequence, which includes a polymorphism, has 92% DNA sequence identity with rat mGluR7 and the predicted protein sequence has 99% identity. In-situ hybridization studies on human brain sections showed that mGluR7 mRNA has a widespread distribution with highest levels in the hippocampal formation, cerebral cortex and cerebellum.

引用

页码：165 / 170

页数：6

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