The Importance of the PI3K/AKT/MTOR Pathway in the Progression of Ovarian Cancer

被引：194

作者：

Dobbin, Zachary C. ^{[1
]}

Landen, Charles N. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Wallace Tumor Inst, Dept Obstet & Gynecol, Div Gynecol Oncol, Birmingham, AL 35233 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 04期

基金：

美国国家卫生研究院;

关键词：

ovarian cancer; PI3K; mTOR; AKT; FATTY-ACID SYNTHASE; TUMOR INVASION; MATRIX METALLOPROTEINASES; ANTITUMOR-ACTIVITY; MAMMALIAN PROTEIN; CELL; AKT; PROLIFERATION; EXPRESSION; MIGRATION;

D O I：

10.3390/ijms14048213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Ovarian cancer is the fifth most common cause of death due to cancer in women despite being the tenth in incidence. Unfortunately, the five-year survival rate is only 45%, which has not improved much in the past 30 years. Even though the majority of women have successful initial therapy, the low rate of survival is due to the eventual recurrence and succumbing to their disease. With the recent release of the Cancer Genome Atlas for ovarian cancer, it was shown that the PI3K/AKT/mTOR pathway was one of the most frequently mutated or altered pathways in patients' tumors. Researching how the PI3K/AKT/mTOR pathway affects the progression and tumorigensis of ovarian cancer will hopefully lead to new therapies that will increase survival for women. This review focuses on recent research on the PI3K/AKT/mTOR pathway and its role in the progression and tumorigensis of ovarian cancer.

引用

页码：8213 / 8227

页数：15

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