Interleukin-1α-889 C/T Polymorphism in Turkish Patients with Late-Onset Alzheimer's Disease

被引：14

作者：

Dursun, Erdinc ^{[1
,2
]}

Gezen-Ak, Duygu ^{[1
,2
]}

Ertan, Turan

Bilgic, Basar ^{[5
]}

Gurvit, Hakan ^{[4
]}

Emre, Murat ^{[4
]}

Eker, Engin

Engin, Funda

Uysal, Oemer ^{[3
]}

Yilmazer, Selma ^{[1
,2
]}

机构：

[1] Istanbul Univ, Cerrahpasa Fac Med, Dept Med Biol, Istanbul, Turkey

[2] Istanbul Univ, Cerrahpasa Fac Med, Dept Geropsychiat, Istanbul, Turkey

[3] Istanbul Univ, Cerrahpasa Fac Med, Dept Biostat, Istanbul, Turkey

[4] Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav & Movement Disorders Unit, Istanbul, Turkey

[5] Istanbul Neuropsychiat Hosp, Dept Neurol, Istanbul, Turkey

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2009年 / 27卷 / 01期

关键词：

Alzheimer's disease; Inflammation; Interleukin-1; gene; Polymorphism; Polymerase chain reaction with confronting two-pair primers; Brain aging; AMYLOID BETA-PROTEIN; GENE POLYMORPHISMS; COMPLEX DISEASE; ASSOCIATION; CYTOKINES; RISK; INFLAMMATION; INTERLEUKIN; NEUROINFLAMMATION; ASTROCYTES;

D O I：

10.1159/000193627

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Background/Aims: The polymorphism (rs1800587) in the 5'-flanking regulatory region at -889 of the interleukin-1 alpha gene has been shown to be associated with inflammatory diseases and Alzheimer's disease (AD). The aim of the current study is to determine whether there is an association between the promoter region polymorphism of the interleukin-1 alpha gene and late-onset AD in a cohort of Turkish patients. Methods: One hundred and four subjects with dementia of the Alzheimer type and 103 age-matched controls were genotyped according to the PCR with confronting two-pair primers method. Results: Although the distribution of genotypes did not significantly differ (p = 0.107), the difference between allelic frequency was nearly significant according to a chi(2) test ( p = 0.05) when the controls and patients were compared. Conclusion: Our results showed that there is no association between the -889 C/T transition on the interleukin-1 alpha gene and late-onset AD in the Turkish population. Copyright (c) 2009 S. Karger AG, Basel

引用

页码：82 / 87

页数：6

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