A new locus on chromosome 19 linked with late-onset Alzheimer's disease

被引：8

作者：

Poduslo, SE ^{[1
]}

Yin, X ^{[1
]}

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Div Neurol, Lubbock, TX 79430 USA

来源：

NEUROREPORT | 2001年 / 12卷 / 17期

关键词：

Alzheimer's disease; chromosome; 19;

D O I：

10.1097/00001756-200112040-00031

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease (AD) is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology. APOE 4 and APOCI A on chromosome 19 are risk factors for late-onset disease. Using large extended families with multiple siblings affected, we have identified several microsatellite markers which are also linked with late-onset Alzheimer's disease. These microsatellites are distal from the apolipoprotein cluster on chromosome 19. It is likely that multiple genes will be involved with late-onset disease, either as risk factors or as causative agents. NeuroReport 12:3759-3761 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：3759 / 3761

页数：3

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