Association between hyperhomocysteinaemia and hypertension in Sri Lankans

被引：52

作者：

Mendis, S ^{[1
]}

Athauda, SBP

Naser, M

Takahashi, K

机构：

[1] Fac Med, Dept Med, Peradeniya, Sri Lanka

[2] Fac Med, Dept Biochem, Peradeniya, Sri Lanka

[3] Univ Tokyo, Dept Mol Biochem, Tokyo, Japan

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1999年 / 27卷 / 01期

关键词：

hypertension; Sri Lankans; hyperhomocysteinaemia;

D O I：

10.1177/030006059902700105

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This study examined the relationship between homocysteine and its metabolites, and hypertension in a cohort of Sri Lankan patients with essential hypertension, Serum homocysteine, cysteine, cysteinylglycine and glutathione were measured in 86 patients with a diagnosis of essential hypertension and compared with those of an age- and sex-matched control group, Patients with hypertension had significantly higher mean serum concentrations of homocysteine, cysteine and cysteinylglycine, The odds ratio for hypertension for those with a mean serum homocysteine concentration above 18 mu mol/l was 2.8. Hyperhomocysteinaemia is a risk factor for hypertension in Sri Lankans and can lead to a threefold increase in risk.

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页码：38 / 44

页数：7

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