On the use of Mendelian randomization to infer causality in observational epidemiology

被引：18

作者：

Bochud, Murielle ^{[1
]}

机构：

[1] Inst Univ Med Sociale & Prevent, Community Prevent Unit, CH-1005 Lausanne, Switzerland

来源：

EUROPEAN HEART JOURNAL | 2008年 / 29卷 / 20期

关键词：

D O I：

10.1093/eurheartj/ehn428

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

引用

收藏

页码：2456 / 2457

页数：2

相关论文

共 13 条

[1]

A cautionary note on the use of Mendelian randomization to infer causation in observational epidemiology [J].

Bochud, Murielle ;

Chiolero, Arnaud ;

Elston, Robert C. ;

Paccaud, Fred .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2008, 37 (02) :414-416

[2]

Insight into the nature of the CRP-coronary event association using Mendelian randomization [J].

Casas, Juan P. ;

Shah, Tina ;

Cooper, Jackie ;

Hawe, Emma ;

McMahon, Alex D. ;

Gaffney, Dairena ;

Packard, Christopher J. ;

O'Reilly, Denis S. ;

Juhan-Vague, Irene ;

Yudkin, John S. ;

Tremoli, Elena ;

Margaglione, Maurizio ;

Di Minno, Giovanni ;

Hamsten, Anders ;

Kooistra, Teake ;

Stephens, Jeffrey W. ;

Hurel, Steven J. ;

Livingstone, Shona ;

Colhoun, Helen M. ;

Miller, George J. ;

Bautista, Leonelo E. ;

Meade, Tom ;

Sattar, Naveed ;

Humphries, Steve E. ;

Hingorani, Aroon D. .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2006, 35 (04) :922-931

[3]

Mendelian randomization as an instrumental variable approach to causal inference [J].

Didelez, Vanessa ;

Sheehan, Nuala .

STATISTICAL METHODS IN MEDICAL RESEARCH, 2007, 16 (04) :309-330

[4]

Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? [J].

Ebrahim, Shah ;

Smith, George Davey .

HUMAN GENETICS, 2008, 123 (01) :15-33

[5]

Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study [J].

Kivimaki, Mika ;

Smith, George Davey ;

Timpson, Nic J. ;

Lawlor, Debbie A. ;

Batty, G. David ;

Kahonen, Mika ;

Juonala, Markus ;

Ronnemaa, Tapani ;

Viikari, Jorma S. A. ;

Lehtimaki, Terho ;

Raitakari, Olli T. .

EUROPEAN HEART JOURNAL, 2008, 29 (20) :2552-2560

[6]

Mendelian randomization suggests no causal association between C-reactive protein and carotid intima-media thickness in the Young Finns study [J].

Kivimaki, Mika ;

Lawlor, Debbie A. ;

Eklund, Carita ;

Smith, George Davey ;

Hurme, Mikko ;

Lehtimaki, Terho ;

Viikari, Jorma S. A. ;

Raitakari, Olli T. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2007, 27 (04) :978-979

[7]

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology [J].

Lawlor, Debbie A. ;

Harbord, Roger M. ;

Sterne, Jonathan A. C. ;

Timpson, Nic ;

Smith, George Davey .

STATISTICS IN MEDICINE, 2008, 27 (08) :1133-1163

[8]

Limits to causal inference based on mendelian randomization: A comparison with randomized controlled trials [J].

Nitsch, D ;

Molokhia, M ;

Smeeth, L ;

DeStavola, BL ;

Whittaker, JC ;

Leon, DA .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2006, 163 (05) :397-403

[9]

Mendelian randomization: prospects, potentials, and limitations [J].

Smith, GD ;

Ebrahim, S .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2004, 33 (01) :30-42

[10]

Association of C-reactive protein with blood pressure and hypertension - Life course confounding and Mendelian randomization tests of causality [J].

Smith, GD ;

Lawlor, DA ;

Harbord, R ;

Timpson, N ;

Rumley, A ;

Lowe, GDO ;

Day, INM ;

Ebrahim, S .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (05) :1051-1056