Alcoholic hepatitis as a T-cell mediated disorder: An hypothesis

被引:9
作者
Batey, RG [1 ]
Clancy, RL
Pang, GT
Cao, Q
机构
[1] John Hunter Hosp, Dept Gastroenterol, Newcastle, NSW 2310, Australia
[2] Univ Newcastle, Discipline Immunol & Microbiol, Newcastle, NSW 2308, Australia
关键词
alcohol; hepatitis; T lymphocyte; cytokines;
D O I
10.1097/00000374-199907000-00010
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Background: The mechanism by which alcohol induces alcoholic hepatitis, the precursor lesion for cirrhosis, has never been elucidated. In particular, direct toxicity has not been proven. This article reviews the hypothesis that a primary target of chronic alcohol ingestion is the T lymphocyte. The lesion in the T lymphocyte is characterized by reduced baseline secretion of cytokines, including tumor necrosis factor-alpha; although characterized by an exaggerated release of cytokines when stimulated by polyclonal activators such as endotoxin. High concentrations of cytokines, especially tumor necrosis factor-alpha, within the liver induce necrosis/apoptosis of hepatocytes. Methods: Data supporting this hypothesis in rodent models are reviewed. Conclusion: A strategic approach for testing this concept in man is defined.
引用
收藏
页码:1207 / 1209
页数:3
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