High-throughput sequencing of B- and T-lymphocyte antigen receptors in hematology

被引：23

作者：

Warren, Edus H. ^{[1
,2
]}

Matsen, Frederick A. ^{[3
]}

Chou, Jeffrey ^{[1
,2
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Clin Res, Program Immunol, Seattle, WA 98104 USA

[2] Univ Washington, Dept Med, Seattle, WA USA

[3] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Computat Biol, Seattle, WA 98104 USA

来源：

BLOOD | 2013年 / 122卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; STEM-CELL TRANSPLANTATION; MINIMAL RESIDUAL DISEASE; IMMUNOGLOBULIN HEAVY; REPERTOIRE; DIVERSITY; COMPLEX; NUMBER;

D O I：

10.1182/blood-2013-03-453142

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Application of high-throughput DNA sequencing to the analysis of B- and T-lymphocyte antigen receptors has great potential for improving the monitoring of lymphoid malignancies, assessing immune reconstitution after hematopoietic cell transplantation, and characterizing the composition of lymphocyte repertoires. Current technology can define the number and frequency of immunoglobulin heavy, T-cell receptor (TCR)alpha, TCR beta, or TCR gamma chains expressed in a population of lymphocytes; techniques for determining the number of antigen receptor heterodimers, such as TCR alpha beta pairs, expressed in the population are under development.

引用

页码：19 / 22

页数：4

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