Autophagy and Viruses: Adversaries or Allies?

被引：185

作者：

Dong, Xiaonan ^{[1
,2
]}

Levine, Beth ^{[1
,2
,3
,4
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Ctr Autophagy Res, Dallas, TX 75390 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Dept Microbiol, Dallas, TX 75390 USA

[4] Univ Texas SW Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA

来源：

JOURNAL OF INNATE IMMUNITY | 2013年 / 5卷 / 05期

关键词：

Autophagy; Virophagy; Antiviral immunity; HEPATITIS-C VIRUS; INFLUENZA-A VIRUS; TRIGGERS AUTOPHAGY; CELL-DEATH; B-VIRUS; DENDRITIC CELLS; LETHAL DISEASE; GENE ATG16L1; PROTEIN ATG5; REPLICATION;

D O I：

10.1159/000346388

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The autophagy pathway is an essential component of host defense against viral infection, orchestrating pathogen degradation (xenophagy), innate immune signaling, and certain aspects of adaptive immunity. Single autophagy proteins or cassettes of the core autophagy machinery can also function as antiviral factors independently of the canonical autophagy pathway. Moreover, to survive and propagate within the host, viruses have evolved a variety of strategies to evade autophagic attack and manipulate the autophagy machinery for their own benefit. This review summarizes recent advances in understanding the antiviral and proviral roles of autophagy and previously unappreciated autophagy-independent functions of autophagy-related genes. Copyright (c) 2013 S. Karger AG, Basel

引用

页码：480 / 493

页数：14

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