The evolution of the cancer niche during multistage carcinogenesis

被引:227
作者
Barcellos-Hoff, Mary Helen [1 ]
Lyden, David [2 ,3 ]
Wang, Timothy C. [4 ,5 ]
机构
[1] NYU, Dept Radiat Oncol, Sch Med, New York, NY 10016 USA
[2] Weill Cornell Med Coll, Childrens Canc & Blood Fdn Labs, Dept Pediat, New York, NY 10021 USA
[3] Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY 10021 USA
[4] Columbia Univ, Med Ctr, Dept Med, New York, NY 10032 USA
[5] Columbia Univ, Med Ctr, Irving Canc Res Ctr, New York, NY 10032 USA
基金
美国国家航空航天局;
关键词
HEMATOPOIETIC STEM-CELL; MYELOID CELLS; STROMAL FIBROBLASTS; IONIZING-RADIATION; SUPPRESSOR-CELLS; BREAST-CANCER; TUMOR-GROWTH; IN-VIVO; CHROMOSOMAL INSTABILITY; PROGENITOR CELLS;
D O I
10.1038/nrc3536
中图分类号
R73 [肿瘤学];
学科分类号
100214 [肿瘤学];
摘要
The concept of the tumour microenvironment recognizes that the interplay between cancer cells and stromal cells is a crucial determinant of cancer growth. In this Perspectives article, we propose the novel concept that the tumour microenvironment is built through rate-limiting steps during multistage carcinogenesis. Construction of a 'precancer niche' is a necessary and early step that is required for initiated cells to survive and evolve; subsequent niche expansion and maturation accompany tumour promotion and progression, respectively. As such, cancer niches represent an emergent property of a tumour that could be a robust target for cancer prevention and therapy.
引用
收藏
页码:511 / 518
页数:8
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