Evidence for postjunctional serotonin (5-HT1) receptors in the trigeminocervical complex

被引：29

作者：

Goadsby, PJ ^{[1
]}

Akerman, S ^{[1
]}

Storer, RJ ^{[1
]}

机构：

[1] UCL Natl Hosp Neurol & Neurosurg, Inst Neurol, Headache Grp, London WC1N 3BG, England

来源：

ANNALS OF NEUROLOGY | 2001年 / 50卷 / 06期

关键词：

D O I：

10.1002/ana.10066

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Units linked to stimulation of the superior sagittal sinus were identified and recorded from in the trigeminocervical complex of the anesthetized cat. Iontophoresis of glutamate NMDA receptor agonists increased the baseline-firing rate of these neurons. Coejection of sumatriptan, 4991W93, or ergometrine resulted in a significant reduction in NMDA agonist-induced increases in firing. These data establish the existence of triptan-sensitive (5-HT1) receptors on postsynaptic central trigeminal neurones.

引用

页码：804 / 807

页数：4

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