Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation

被引：46

作者：

Arshavsky, VY ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA

[2] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA

来源：

TRENDS IN NEUROSCIENCES | 2002年 / 25卷 / 03期

关键词：

D O I：

10.1016/S0166-2236(00)02094-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Rhodopsin phosphorylation has provided one of the first examples of the ubiquitous regulatory pattern of specific kinases downregulating the activity of G-protein-coupled receptors. However, only recently have studies in living animals allowed us to consider the role of rhodopsin phosphorylation in a broader spectrum of visual functions, ranging from the ability of rods to generate reproducible electrical responses to their ability to adapt to darkness after substantial light exposures.

引用

页码：124 / 126

页数：3

共 16 条

[1]

ARSHAVSKY VY, 1987, RETINAL PROTEINS, P497

[2]

BAYLOR DA, 1979, J PHYSIOL-LONDON, V288, P613

[3] Activation, deactivation, and adaptation in vertebrate, photoreceptor cells [J].

Burns, ME ;

Baylor, DA .

ANNUAL REVIEW OF NEUROSCIENCE, 2001, 24 :779-805

[4] Adaptation in vertebrate photoreceptors [J].

Fain, GL ;

Matthews, HR ;

Cornwall, MC ;

Koutalos, Y .

PHYSIOLOGICAL REVIEWS, 2001, 81 (01) :117-151

[5] Multiple phosphorylation of rhodopsin and the in vivo chemistry underlying rod photoreceptor dark adaptation [J].

Kennedy, MJ ;

Lee, KA ;

Niemi, GA ;

Craven, KB ;

Garwin, GG ;

Saari, JC ;

Hurley, JB .

NEURON, 2001, 31 (01) :87-101

[6] Structural features of the C-terminal domain of bovine rhodopsin: A site-directed spin-labeling study [J].

Langen, R ;

Cai, KW ;

Altenbach, C ;

Khorana, HG ;

Hubbell, WL .

BIOCHEMISTRY, 1999, 38 (25) :7918-7924

[7] Molecular basis of dark adaptation in rod photoreceptors [J].

Leibrock, CS ;

Reuter, T ;

Lamb, TD .

EYE, 1998, 12 (3) :511-520

[8] Rapid and reproducible deactivation of rhodopsin requires multiple phosphorylation sites [J].

Mendez, A ;

Burns, ME ;

Roca, A ;

Lem, J ;

Wu, LW ;

Simon, MI ;

Baylor, DA ;

Chen, J .

NEURON, 2000, 28 (01) :153-164

[9] RHODOPSIN PHOSPHORYLATION AND DEPHOSPHORYLATION IN-VIVO [J].

OHGURO, H ;

VANHOOSER, JP ;

MILAM, AH ;

PALCZEWSKI, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (24) :14259-14262

[10]

Pugh Jr E, 2000, HDB BIOL PHYSICS, P183, DOI DOI 10.1016/S1383-8121(00)80008-1

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