Can we discover novel pathways using metabolomic analysis?

被引:128
作者
Weckwerth, W [1 ]
Fiehn, O [1 ]
机构
[1] Max Planck Inst Mol Plant Physiol, Dept Willmitzer, D-14424 Potsdam, Germany
关键词
D O I
10.1016/S0958-1669(02)00299-9
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Metabolomic analysis aims at the identification and quantitation of all metabolites in a given biological sample. Current data acquisition and network analysis strategies are classified on the basis of pathway elucidation and characteristics of theoretical networks. The development of metabolomic methods and tools is progressing rapidly, but an understanding of the resulting data is limited owing to a fundamental lack of biochemical and physiological knowledge about network organization in plants.
引用
收藏
页码:156 / 160
页数:5
相关论文
共 69 条
[1]   Classes of small-world networks [J].
Amaral, LAN ;
Scala, A ;
Barthélémy, M ;
Stanley, HE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11149-11152
[2]   Automated mode-of-action detection by metabolic profiling [J].
Aranìbar, N ;
Singh, BK ;
Stockton, GW ;
Ott, KH .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 286 (01) :150-155
[3]   A test case of correlation metric construction of a reaction pathway from measurements [J].
Arkin, A ;
Shen, PD ;
Ross, J .
SCIENCE, 1997, 277 (5330) :1275-1279
[4]   High sensitivity analysis of neutral underivatized oligosaccharides by nanoelectrospray mass spectrometry [J].
Bahr, U ;
Pfenninger, A ;
Karas, M ;
Stahl, B .
ANALYTICAL CHEMISTRY, 1997, 69 (22) :4530-4535
[5]   Pressurized liquid extraction of medicinal plants [J].
Benthin, B ;
Danz, H ;
Hamburger, M .
JOURNAL OF CHROMATOGRAPHY A, 1999, 837 (1-2) :211-219
[6]   Fractionation of plant extracts by supercritical fluid extraction and direct introduction in capillary gas chromatography using a programmable temperature vaporizer [J].
Blanch, GP ;
Caja, MM ;
del Castillo, MLR ;
Santa-María, G ;
Herraiz, M .
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1999, 37 (10) :407-410
[7]   Analysis of amines in plant materials [J].
Bouchereau, A ;
Guénot, P ;
Lather, F .
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2000, 747 (1-2) :49-67
[8]   Rapid and complete extraction of phenols from olive oil and determination by means of a coulometric electrode array system [J].
Brenes, M ;
García, A ;
García, P ;
Garrido, A .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2000, 48 (11) :5178-5183
[9]   GLEICHGEWICHT UND UNGLEICHGEWICHT IM SYSTEM DER GLYKOLYSE [J].
BUCHER, T ;
RUSSMANN, W .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1963, 75 (19) :881-+
[10]  
CASTIONI P, 1995, ANALUSIS, V23, P95