Can we discover novel pathways using metabolomic analysis?

被引：128

作者：

Weckwerth, W ^{[1
]}

Fiehn, O ^{[1
]}

机构：

[1] Max Planck Inst Mol Plant Physiol, Dept Willmitzer, D-14424 Potsdam, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2002年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0958-1669(02)00299-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolomic analysis aims at the identification and quantitation of all metabolites in a given biological sample. Current data acquisition and network analysis strategies are classified on the basis of pathway elucidation and characteristics of theoretical networks. The development of metabolomic methods and tools is progressing rapidly, but an understanding of the resulting data is limited owing to a fundamental lack of biochemical and physiological knowledge about network organization in plants.

引用

页码：156 / 160

页数：5

共 69 条

[11] Effect of liquid chromatography separation of complex matrices on liquid chromatography-tandem mass spectrometry signal suppression [J].

Choi, BK ;

Hercules, DM ;

Gusev, AI .

JOURNAL OF CHROMATOGRAPHY A, 2001, 907 (1-2) :337-342

[12] Carbon and nitrogen sensing and signaling in plants: emerging 'matrix effects' [J].

Coruzzi, GM ;

Zhou, L .

CURRENT OPINION IN PLANT BIOLOGY, 2001, 4 (03) :247-253

[13] Genetic variability of proteome expression and metabolic control [J].

de Vienne, D ;

Bost, B ;

Fiévet, J ;

Zivy, M ;

Dillmann, C .

PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2001, 39 (3-4) :271-283

[14] In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data [J].

Edwards, JS ;

Ibarra, RU ;

Palsson, BO .

NATURE BIOTECHNOLOGY, 2001, 19 (02) :125-130

[15]

Farré EM, 2001, PLANT PHYSIOL, V127, P685, DOI 10.1104/pp.127.2.685

[16]

Fell D., 1997, Understanding the control of metabolism

[17] The small world of metabolism [J].

Fell, DA ;

Wagner, A .

NATURE BIOTECHNOLOGY, 2000, 18 (11) :1121-1122

[18] Carotenoid determination in biological microsamples using liquid chromatography with a coulometric electrochemical array detector [J].

Ferruzzi, MG ;

Sander, LC ;

Rock, CL ;

Schwartz, SJ .

ANALYTICAL BIOCHEMISTRY, 1998, 256 (01) :74-81

[19] Analysis of lycopene geometrical isomers in biological microsamples by liquid chromatography with coulometric array detection [J].

Ferruzzi, MG ;

Nguyen, ML ;

Sander, LC ;

Rock, CL ;

Schwartz, SJ .

JOURNAL OF CHROMATOGRAPHY B, 2001, 760 (02) :289-299

[20] Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry [J].

Fiehn, O ;

Kopka, J ;

Trethewey, RN ;

Willmitzer, L .

ANALYTICAL CHEMISTRY, 2000, 72 (15) :3573-3580

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