Current views on the population structure of Plasmodium falciparum: Implications for control

被引:100
作者
Babiker, HA
Walliker, D
机构
[1] Inst. of Cell, Anim. and Pop. Biol., University of Edinburgh, Ashworth Laboratories, Edinburgh, EH9 3JT, West Mains Road
来源
PARASITOLOGY TODAY | 1997年 / 13卷 / 07期
基金
英国惠康基金;
关键词
D O I
10.1016/S0169-4758(97)01075-2
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
In recent years there has been a considerable debate on the population genetic structure of malaria parasites. Work on this subject has been revolutionized by the advent of the polymerase chain reaction (PCR) technique, which has made it feasible to study the genetic diversity of parasites in small samples of infected blood, allowing extensive surveys of natural parasite populations to be made. In addition, the technique can be applied to the mosquito stages of the malaria parasite, allowing direct assessments to be made of the frequency of crossing between parasite clones in Nature. Studies on Plasmodium falciparum in a wide range of malaria-endemic regions are now revealing the relationship between parasite population structure and malaria epidemiology. In this article, Hamza Babiker and David Walliker review recent work in this field, and discuss how such knowledge might be used to advise on the future depolyment of control measures such as antimalarial drugs and possible malaria vaccines.
引用
收藏
页码:262 / 267
页数:6
相关论文
共 55 条
  • [1] DIGITAL CODES FROM HYPERVARIABLE TANDEMLY REPEATED DNA-SEQUENCES IN THE PLASMODIUM-FALCIPARUM CIRCUMSPOROZOITE GENE CAN GENETICALLY BARCODE ISOLATES
    ARNOT, DE
    ROPER, C
    BAYOUMI, RAL
    [J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1993, 61 (01) : 15 - 24
  • [2] GENETIC DIVERSITY OF PLASMODIUM-FALCIPARUM IN A VILLAGE IN EASTERN SUDAN .1. DIVERSITY OF ENZYMES, 2D-PAGE PROTEINS AND ANTIGENS
    BABIKER, HA
    CREASEY, AM
    FENTON, B
    BAYOUMI, RAL
    ARNOT, DE
    WALLIKER, D
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (05) : 572 - 577
  • [3] RANDOM MATING IN A NATURAL-POPULATION OF THE MALARIA PARASITE PLASMODIUM-FALCIPARUM
    BABIKER, HA
    RANFORDCARTWRIGHT, LC
    CURRIE, D
    CHARLWOOD, JD
    BILLINGSLEY, P
    TEUSCHER, T
    WALLIKER, D
    [J]. PARASITOLOGY, 1994, 109 : 413 - 421
  • [4] Population structure of Plasmodium falciparum in villages with different malaria endemicity in east Africa
    Babiker, HA
    Lines, J
    Hill, WG
    Walliker, D
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1997, 56 (02) : 141 - 147
  • [5] Beale G.H., 1978, P213
  • [6] MALARIA SPOROZOITES - SURVIVAL, TRANSMISSION AND DISEASE-CONTROL
    BEIER, JC
    [J]. PARASITOLOGY TODAY, 1993, 9 (06): : 210 - 215
  • [7] PLASMODIUM-FALCIPARUM INCIDENCE RELATIVE TO ENTOMOLOGIC INOCULATION RATES AT A SITE PROPOSED FOR TESTING MALARIA VACCINES IN WESTERN KENYA
    BEIER, JC
    OSTER, CN
    ONYANGO, FK
    BALES, JD
    SHERWOOD, JA
    PERKINS, PV
    CHUMO, DK
    KOECH, DV
    WHITMIRE, RE
    ROBERTS, CR
    DIGGS, CL
    HOFFMAN, SL
    [J]. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1994, 50 (05) : 529 - 536
  • [8] ENZYME VARIATION IN PLASMODIUM-FALCIPARUM IN GAMBIA
    CARTER, R
    MCGREGOR, IA
    [J]. TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1973, 67 (06) : 830 - 837
  • [9] DENSITY-INDEPENDENT FEEDING SUCCESS OF MALARIA VECTORS (DIPTERA, CULICIDAE) IN TANZANIA
    CHARLWOOD, JD
    SMITH, T
    KIHONDA, J
    HEIZ, B
    BILLINGSLEY, PF
    TAKKEN, W
    [J]. BULLETIN OF ENTOMOLOGICAL RESEARCH, 1995, 85 (01) : 29 - 35
  • [10] BLOOD-FEEDING AND RESTING BEHAVIOR IN THE ANOPHELES-PUNCTULATUS DONITZ COMPLEX (DIPTERA, CULLICIDAE) FROM COASTAL PAPUA-NEW-GUINEA
    CHARLWOOD, JD
    DAGORO, H
    PARU, R
    [J]. BULLETIN OF ENTOMOLOGICAL RESEARCH, 1985, 75 (03) : 463 - 475