The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction

被引：158

作者：

Wan, Y

Liu, XD

Kirschner, MW ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[2] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

来源：

MOLECULAR CELL | 2001年 / 8卷 / 05期

关键词：

D O I：

10.1016/S1097-2765(01)00382-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Degradation of SnoN is thought to play an important role in the transactivation of TGF-P responsive genes. We demonstrate that the anaphase-promoting complex (APC) is a ubiquitin ligase required for the destruction of SnoN and that the APC pathway is regulated by TGF-beta. The destruction box of SnoN is required for its degradation in response to TGF-P signaling. Furthermore, the APC activator CDH1 and Smad3 synergistically regulate SnoN degradation. Under these circumstances, CDH1 forms a quaternary complex with SnoN, Smad3, and APC. These results suggest that APC(CDH1) and SnoN play central roles in regulating growth through the TGF-beta signaling system.

引用

收藏

页码：1027 / 1039

页数：13

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