Understanding the Sexome: Measuring and Reporting Sex Differences in Gene Systems

被引：74

作者：

Arnold, Arthur P. ^{[1
,7
]}

Lusis, Aldons J. ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Univ Calif Los Angeles, Dept Integrat Biol & Physiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Med, David Geffen Sch Med, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Microbiol, David Geffen Sch Med, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Dept Immunol, David Geffen Sch Med, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Dept Mol Genet, David Geffen Sch Med, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Dept Human Genet, David Geffen Sch Med, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, Neuroendocrinol Lab, Brain Res Inst, Los Angeles, CA 90095 USA

来源：

ENDOCRINOLOGY | 2012年 / 153卷 / 06期

基金：

美国国家卫生研究院;

关键词：

QUANTITATIVE TRAIT LOCI; EXPRESSION; GENDER; BRAIN; ARCHITECTURE; NETWORK; HEART; MICE;

D O I：

10.1210/en.2011-2134

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The current male bias in biomedical research should be eliminated. The large sex differences in incidence and progression of diseases mean that sex-biased factors are an untapped source of factors that protect from disease. Greater understanding will come from intensified study of the "sexome,"which is the sum of sex-biased effects on gene networks and cell systems. The global search for sites and mechanisms of sex-specific regulation in diverse tissues will provide unanticipated insights into physiological regulation and targets for novel therapies. (Endocrinology 153: 2551-2555, 2012)

引用

页码：2551 / 2555

页数：5

共 43 条

[1]

Comparative proteomics of human male and female tears by two-dimensional electrophoresis [J].

Ananthi, Sivagnanam ;

Santhosh, Ramachandran Sarojini ;

Nila, Murugesan Valar ;

Prajna, Namperumalsamy Venkatesh ;

Lalitha, Prajna ;

Dharmalingam, Kuppamuthu .

EXPERIMENTAL EYE RESEARCH, 2011, 92 (06) :454-463

[2]

The end of gonad-centric sex determination in mammals [J].

Arnold, Arthur P. .

TRENDS IN GENETICS, 2012, 28 (02) :55-61

[3]

Promoting the understanding of sex differences to enhance equity and excellence in biomedical science [J].

Arthur P Arnold .

Biology of Sex Differences, 1 (1)

[4]

The organizational-activational hypothesis as the foundation for a unified theory of sexual differentiation of all mammalian tissues [J].

Arnold, Arthur P. .

HORMONES AND BEHAVIOR, 2009, 55 (05) :570-578

[5]

Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus: support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants [J].

Avery, C. L. ;

Freedman, B. I. ;

Kraja, A. T. ;

Borecki, I. B. ;

Miller, M. B. ;

Pankow, J. S. ;

Arnett, D. ;

Lewis, C. E. ;

Myers, R. H. ;

Hunt, S. C. ;

North, K. E. .

DIABETOLOGIA, 2006, 49 (10) :2329-2336

[6]

Sex bias in neuroscience and biomedical research [J].

Beery, Annaliese K. ;

Zucker, Irving .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2011, 35 (03) :565-572

[7]

Gene expression changes in the course of normal brain aging are sexually dimorphic [J].

Berchtold, Nicole C. ;

Cribbs, David H. ;

Coleman, Paul D. ;

Rogers, Joseph ;

Head, Elizabeth ;

Kim, Ronald ;

Beach, Tom ;

Miller, Carol ;

Troncoso, Juan ;

Trojanowski, John Q. ;

Zielke, H. Ronald ;

Cotman, Carl W. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (40) :15605-15610

[8]

The evolution of chromosomal sex determination and dosage compensation [J].

Charlesworth, B .

CURRENT BIOLOGY, 1996, 6 (02) :149-162

[9]

Estrogen Receptor α Controls a Gene Network in Luminal-Like Breast Cancer Cells Comprising Multiple Transcription Factors and MicroRNAs [J].

Cicatiello, Luigi ;

Mutarelli, Margherita ;

Grober, Ohi M. V. ;

Paris, Ornella ;

Ferraro, Lorenzo ;

Ravo, Maria ;

Tarallo, Roberta ;

Luo, Shujun ;

Schroth, Gary P. ;

Seifert, Martin ;

Zinser, Christian ;

Chiusano, Maria Luisa ;

Traini, Alessandra ;

De Bortoli, Michele ;

Weisz, Alessandro .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 176 (05) :2113-2130

[10]

Minireview: Sex differences in adult and developing brains: Compensation, compensation, compensation [J].

De Vries, GJ .

ENDOCRINOLOGY, 2004, 145 (03) :1063-1068

← 1 2 3 4 5 →