Effect of chronic inhalation of toluene and dioxane on activity of free radical processes in rat ovaries and brain

被引：34

作者：

Burmistrov, SO ^{[1
]}

Arutyunyan, AV ^{[1
]}

Stepanov, MG ^{[1
]}

Oparina, TI ^{[1
]}

Prokopenko, VM ^{[1
]}

机构：

[1] Russian Acad Med Sci, DO Ott Inst Obstet & Gynecol, Lab Perinatal Biochem, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 132卷 / 03期

关键词：

toluene; dioxane; free radicals; ovaries; brain; circadian rhythms;

D O I：

10.1023/A:1013106315140

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

(T)he effects of toluene and dioxane inhalations on the intensity of free radical oxidation in rat ovaries and brain cortex were studied. Both toxins in a dose 10-fold surpassing the maximum permissible concentration increased activity of glutathione peroxidase in brain tissue; moreover, toluene increased chemiluminescence intensity, which attested to activation of free radical processes. In ovarian tissue toluene increased activities of glutathione peroxidase and catalase and the intensity of lipid peroxidation. These changes were associated with the appearance of normally absent circadian rhythm.

引用

页码：832 / 836

页数：5

共 13 条

[1] AGOSTINI A, 1980, J CLIN CHEM CLIN BIO, V17, P771
[2] AILAMAZYAN EK, 1997, VESTN ROSS ASSOTSIAT, P72
[3] Arushanyan E. B., 1997, Eksperimental'naya i Klinicheskaya Farmakologiya, V60, P71
[4] ARUTYUNYAN AV, VESTN ROSS ASSOTSIAT, P28
[5] ORGAN CHEMI-LUMINESCENCE - NON-INVASIVE ASSAY FOR OXIDATIVE RADICAL REACTIONS
BOVERIS, A
CADENAS, E
REITER, R
FILIPKOWSKI, M
NAKASE, Y
CHANCE, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (01): : 347 - 351
[6] BURMIRSTROV SO, 1992, FARMAKOL TOKSIKOL, P56
[7] NEUROCHEMICAL ORGANIZATION OF CIRCADIAN-RHYTHM IN THE SUPRACHIASMATIC NUCLEUS
INOUYE, SIT
SHIBATA, S
[J]. NEUROSCIENCE RESEARCH, 1994, 20 (02) : 109 - 130
[8] KULINSKII II, 1993, USP SOVREM BIOL, V113, P107
[9] LEVINE RL, 1990, METHOD ENZYMOL, V186, P464
[10] OXYGEN-FREE RADICALS AND HUMAN-DISEASE
MARTINEZCAYUELA, M
[J]. BIOCHIMIE, 1995, 77 (03) : 147 - 161

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