Primordial Germ Cells in Mice

被引：281

作者：

Saitou, Mitinori ^{[1
,2
,3
,4
]}

Yamaji, Masashi ^{[1
,2
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Anat & Cell Biol, Sakyo Ku, Kyoto 6068501, Japan

[2] JST, ERATO, Sakyo Ku, Kyoto 6068501, Japan

[3] Kyoto Univ, Inst Integrated Cell Mat Sci, Sakyo Ku, Kyoto 6068501, Japan

[4] Kyoto Univ, Ctr IPS Cell Res & Applicat, Sakyo Ku, Kyoto 6068507, Japan

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2012年 / 4卷 / 11期

关键词：

LEUKEMIA INHIBITORY FACTOR; PLURIPOTENT STEM-CELLS; DNA METHYLATION; GENE-EXPRESSION; MOUSE EMBRYO; EXTRAEMBRYONIC LINEAGES; EPIGENETIC INHERITANCE; TESTICULAR TERATOMAS; ARGININE METHYLATION; CHROMATIN-STRUCTURE;

D O I：

10.1101/cshperspect.a008375

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Germ cell development creates totipotency through genetic as well as epigenetic regulation of the genome function. Primordial germ cells (PGCs) are the first germ cell population established during development and are immediate precursors for both the oocytes and spermatogonia. We here summarize recent findings regarding the mechanism of PGC development in mice. We focus on the transcriptional and signaling mechanism for PGC specification, potential pluripotency, and epigenetic reprogramming in PGCs and strategies for the reconstitution of germ cell development using pluripotent stem cells in culture. Continued studies on germ cell development may lead to the generation of totipotency in vitro, which should have a profound influence on biological science as well as on medicine.

引用

页数：19

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