Colorectal carcinoma: from tumorigenesis to treatment

被引：33

作者：

Wang, WS

Chen, M

Su, Y ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Fac Life Sci, Inst Biopharmaceut Sci, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 11221, Taiwan

[3] Taipei Vet Gen Hosp, Dept Med, Div Med Oncol, Taipei, Taiwan

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2006年 / 63卷 / 06期

关键词：

colorectal carcinoma; tumorigenesis; staging; matrix metalloproteinase; hedgehog; thymosin beta-4; stem cells; treatment;

D O I：

10.1007/s00018-005-5425-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal carcinoma (CRC) is a complicated and often fatal genetic disease. Fortunately, owing to rapid expansion of knowledge and technology development in oncology, much progress has been made regarding the diagnosis, understanding of the molecular genetics and malignant progression, as well as the novel regimens of CRC. In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog signaling, the intriguing involvement of thymosin beta-4, and the possible contribution of the putative colon (cancer) stem cells in CRC tumorigenesis. Current treatments as well as several potentially applicable therapeutic strategies for CRC are also discussed.

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页码：663 / 671

页数：9

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