Relation between plasma phospholipid saturated fatty acids and hyperinsulinemia

被引:57
作者
Folsom, AR
Ma, J
McGovern, PG
Eckfeldt, JH
机构
[1] Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN
[2] Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454-1015
来源
METABOLISM-CLINICAL AND EXPERIMENTAL | 1996年 / 45卷 / 02期
关键词
D O I
10.1016/S0026-0495(96)90058-X
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We determined whether plasma phospholipid fatty acid levels, an indicator of fatty acid composition in the diet, are associated with fasting serum insulin concentrations (a marker of insulin resistance). We examined cross-sectionally 4,304 middle-aged adults free of diabetes. Plasma fatty acid composition was quantified by gas chromatography. Easting insulin was strongly and positively associated with the saturated fatty acid percentage in plasma phospholipids, moderately and inversely associated with the monounsaturated percentage, and not appreciably associated with the polyunsaturated percentage. Easting insulin adjusted for age, smoking status, alcohol consumption, and sports participation, for example, was 29% higher in men and 33% higher in women per 1.9% greater level of saturated fatty acids (the interquartile range). After adjustment for body mass index (BMI) and other covariates, these estimates were 12% and 15% (P < .01 for the difference from zero). A 1.9% greater increment in saturated fatty acid level was also associated with a 2.4-fold higher odds of hyperinsulinemia (fasting insulin greater than or equal to 143.5 pmol/L). These data are consistent with studies showing that fatty acid composition of cell membranes modulates insulin action, and support the hypothesis that increased habitual saturated fat intake or a related dietary pattern is a risk factor for hyperinsulinemia. (C) 1996 by W.B. Saunders Company
引用
收藏
页码:223 / 228
页数:6
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