Evidence for a mitochondrial impact of trimetazidine during cold ischemia and reperfusion

被引：16

作者：

Baumert, H

Faure, JP

Zhang, KQ

Petit, I

Goujon, JM

Dutheil, D

Favreau, F

Barrière, M

Tillement, JP

Mauco, G

Papadopoulos, V

Hauet, T

机构：

[1] CHU Poitiers, INSERM, ERM 324, FR-86000 Poitiers, France

[2] INRA, Dept Genet Anim, Unite Transplantat Expt, Surgeres, France

[3] Hop Jean Bernard, Ctr Hosp & Univ, Poitiers, France

[4] Georgetown Univ, Med Ctr, Dept Cell Biol, Div Hormone Res, Washington, DC 20007 USA

[5] Fac Med Paris 12, Pharmacol Lab, Creteil, France

[6] Fac Med Paris 12, Ctr Natl Rech Sci, Creteil, France

来源：

PHARMACOLOGY | 2004年 / 71卷 / 01期

关键词：

trimetazidine; cold ischemia; reperfusion injury; kidney preservation; preservation solutions; mitochondria;

D O I：

10.1159/000076259

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In organ transplantation, ischemia-reperfusion injury (IRI) has been implicated in delayed graft function (DGF) as well as in short- and long-term complications. Using an autotransplant pig kidney model, changes in renal function and morphology were determined after different periods of cold ischemia in kidneys preserved in the University of Wisconsin solution (UW), high-Na+ version of UW (HEH) or Celsior (CEL) a newly developed high-Na+ solution, with or without trimetazidine (TMZ). Kidney function was better preserved in CEL, UW and particularly HEH in combination with TMZ, particularly after 48 and 72 h. Mitochondria integrity was improved in TMZ-preserved groups. This study indicates that TMZ is efficiently protective against IRI even after prolonged preservation and in different preservation solutions. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：25 / 37

页数：13

共 45 条

[1] High-Na+ low-K+ UW cold storage solution reduces reperfusion injuries of the rat liver graft [J].